{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:55:44Z","timestamp":1792032944147,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lung transplant recipients are at increased risk of candidemia, especially in the early posttransplant period. However, the specific predisposing factors have not been established. The natural history of candidemia after lung transplantation, in the absence of universal antifungal prophylaxis, is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined the epidemiology of candidemia at any time posttransplant in patients who underwent lung transplantation at our center between 2016 and 2019. We undertook a case\u2010control study and used logistic regression to evaluate the risk factors for candidemia during the first 30 days posttransplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period 712 lung transplants were performed on 705 patients. Twenty\u2010five lung transplant recipients (LTRs) (3.5%) experienced 31 episodes of candidemia. The median time to candidemia was 19.5 days (IQR 10.5\u201370.5), with 61.2% (<jats:italic>n<\/jats:italic> = 19) episodes of candidemia occurring within the first 30 days posttransplantation. Pretransplant hospitalization, posttransplant ECMO, and posttransplant renal replacement therapy were associated with an increased risk of candidemia in the first 30 days posttransplant. Of those with candidemia in the first 30 days, 31.2% died within 30 days of the index positive blood culture. Candidemia was associated with decreased survival within 30 days posttransplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the greatest risk period of lung transplant recipients for development of candidemia and identifies several factors associated with increased risk of candidemia. These findings will help guide future studies on antifungal prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13812","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T11:09:06Z","timestamp":1645268946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiology of candidemia in lung transplant recipients and risk factors for candidemia in the early posttransplant period in the absence of universal antifungal prophylaxis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-787X","authenticated-orcid":false,"given":"Tina","family":"Marinelli","sequence":"first","affiliation":[{"name":"Multi\u2010Organ Transplant Program Division of Infectious Diseases Department of Medicine University of Toronto University Health Network  Toronto Canada"},{"name":"Department of Infectious Diseases Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-5059","authenticated-orcid":false,"given":"Kelly M.","family":"Pennington","sequence":"additional","affiliation":[{"name":"Toronto Lung Transplant Program University Health Network  Toronto Ontario Canada"},{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-7075","authenticated-orcid":false,"given":"Bassem","family":"Hamandi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Health Network  Toronto Ontario Canada"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Donahoe","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Toronto General Hospital University Health Network University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-0968","authenticated-orcid":false,"given":"Coleman","family":"Rotstein","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Program Division of Infectious Diseases Department of Medicine University of Toronto University Health Network  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Martinu","sequence":"additional","affiliation":[{"name":"Toronto Lung Transplant Program University Health Network  Toronto Ontario Canada"},{"name":"Division of Respirology Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-5229","authenticated-orcid":false,"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Program Division of Infectious Diseases Department of Medicine University of Toronto University Health Network  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"269","article-title":"Epidemiological features of invasive mold infections among solid organ transplant recipients: PATH Alliance R registry analysis","author":"Husain S","year":"2017","journal-title":"Med Mycolo"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"issue":"13250","key":"e_1_2_7_4_1","article-title":"Incidence and outcomes of invasive fungal infection among solid organ transplant recipients: a population\u2010based cohort study","volume":"2","author":"Hosseini\u2010Moghaddam SM","year":"2020","journal-title":"Transpl Infect 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