{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:39:21Z","timestamp":1788925161456,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With advancements in allogeneic hematopoietic cell transplantation (alloHCT), the need for cytomegalovirus (CMV) surveillance persists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a retrospective analysis on the impact of CMV with preemptive therapy in 1065 alloHCT patients with donor and\/or recipient CMV seropositivity from 2009 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one percent developed clinically significant CMV infection (CMV\u2010CSI); 6.5% had CMV disease. In multivariate analysis stratified by serostatus and preparative regimen, the use of anti\u2010thymocyte globulin (hazard ratios 2.97, 95% confidence interval 2.00\u20134.42, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) was associated with development of CMV\u2010CSI. Median length of stay for index hospitalization was longer in patients with CMV\u2010CSI (27 vs. 25 days, respectively; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.002), as were rates (32.9%\u00a0vs. 17.7%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001) and duration (9 d vs. 6 d; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001) of rehospitalization, and median total inpatient days (28 d vs. 26 d; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Patients with CMV\u2010CSI had higher rates of neutropenia (47%\u00a0vs. 20%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and transfusion support (packed red blood cell, median 5\u00a0vs. 3; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001; platelets, median 3\u00a0vs. 3; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preemptive therapy does not negate the impact of CMV\u2010CSI on peri\u2010engraftment toxicity and healthcare utilization. This cohort represents a large single center study on the impact of CMV in the preletermovir era and serves as a real\u2010world comparator for assessing the impact of future prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13825","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:14:07Z","timestamp":1648167247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The changing impact of cytomegalovirus among hematopoietic cell transplant recipients during the past decade: A single institutional cohort study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-6394","authenticated-orcid":false,"given":"Joyce J.","family":"Johnsrud","sequence":"first","affiliation":[{"name":"Division of Blood and Marrow Transplantation Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-0267","authenticated-orcid":false,"given":"Isabelle T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Domingo","sequence":"additional","affiliation":[{"name":"Pharmacy Services Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-8612","authenticated-orcid":false,"given":"Amit D.","family":"Raval","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  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Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-7639","authenticated-orcid":false,"given":"Balasubramanian","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Departments of Statistics and Biomedical Data Science Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Efron","sequence":"additional","affiliation":[{"name":"Departments of Statistics and Biomedical Data Science Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-0179","authenticated-orcid":false,"given":"Janice (Wes)","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Infectious Diseases Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.7.2815.2815"},{"key":"e_1_2_9_3_1","first-page":"399","article-title":"Practices for cytomegalovirus diagnosis, prophylaxis and treatment in allogeneic bone marrow transplant recipients: a report from the Working Party for Infectious Diseases of the EBMT","volume":"12","author":"Ljungman P","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702608"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112053252303"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199811270-00012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3263"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.7.2219"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/342332"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.12.4029"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.963079"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.09.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04264.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.09.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13096"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050642"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-211441"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_9_19_1","first-page":"3702","article-title":"Blood stem cells compared to bone marrow as a source of hematopoeitic cells for allogeneic transplantation. 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