{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:38:39Z","timestamp":1762522719253,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Solid\u2010organ transplantation (SOT) remains the best therapeutic option for end\u2010stage organ disease. Regrettably, SOT recipients are disproportionately affected by nosocomial infections produced by multidrug\u2010resistant (MDR) microorganisms and antimicrobial adverse events. Both have a negative impact on the patient\u00b4s outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Description of data concerning the antimicrobial stewardship program (ASP) in SOT recipients of the University Hospital \u201c12 de Octubre\u201d, and review of other Spanish ASPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From May 2017 to December 2021, the ASP issued 2.785 recommendations. Approximately, 4.9% were aimed at improving the antimicrobial treatment administered to SOT recipients. Treatment discontinuation or change to a better therapeutic regimen was recommended in 51.8% and 26.3% of cases, respectively. The acceptance rate of the recommendations was close to 92%. Between June 2015 and March 2016, a quasi\u2010experimental study consisting of a joint ASP and hospital\u2010acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections, and cystitis. Although Spain has several robust regional ASPs (e.g., VINCat and PIRASOA), data specifically concerning SOT patients is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ASP coupled with HAIC programs have proven to be effective in SOT, and should be implemented in centers that perform transplantation. Since data is scarce, Spanish centers which have ASP should report their experience in SOT. Understanding the efficacy and safety of the Spanish ASP\u00b4s intervention in the SOT population is essential and deserves further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13851","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T16:28:49Z","timestamp":1652804929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Current state of antimicrobial stewardship and organ transplantation in Spain"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-3466","authenticated-orcid":false,"given":"Jose Tiago","family":"Silva","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Departamento de Medicina Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-8255","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (i+12) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Departamento de Medicina Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"Global observatory on donation and transplantation. transplant sum: kidney + heart + lung + liver + pancreas + small bowel (Europe 2020).http:\/\/www.transplant\u2010observatory.org\/data\u2010charts\u2010and\u2010tables\/chart\/Accessed February 21 2022"},{"key":"e_1_2_4_3_1","unstructured":"Organizaci\u00f3n Nacional de Trasplantes.Balance de Actividad en 2021.http:\/\/www.ont.es\/Documents\/Balance\/de\/actividad\/Donaci\u00f3n\/y\/Trasplante\/2021_ONT.pdfAccessed February 21 2022"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12687"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0374-5"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12984"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12547"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000488"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000890"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.41089"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13195"},{"issue":"1170","key":"e_1_2_4_12_1","first-page":"e1","article-title":"Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain","volume":"27","author":"Escribano P","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.09.058"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(12)70079-4"},{"issue":"22","key":"e_1_2_4_15_1","first-page":"e1","article-title":"Programs for optimizing the use of antibiotics (PROA) in Spanish hospitals: gEIH\u2010SEIMC, SEFH and SEMPSPH consensus document","volume":"30","author":"Rodriguez\u2010Bano J","year":"2012","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12733"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12364"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000886"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000380"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.213"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13098"},{"key":"e_1_2_4_22_1","first-page":"186","article-title":"Impact of a non\u2010compulsory antibiotic control program (PACTA): cost reductions and decreases in some nosocomial infections","volume":"23","author":"Lopez\u2010Medrano F","year":"2005","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03891.x"},{"key":"e_1_2_4_24_1","unstructured":"L\u00f3pez\u2010MedranoF.A combined strategy of antimicrobial stewardship and hospital\u2010acquired infection control reduced the incidence of bacterial infection in a kidney transplantation programme (Hippomenes\u2010PACTA\u2010PROA study). 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