{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:22:54Z","timestamp":1755796974622,"version":"3.44.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The emergence of coronavirus disease 19 (COVID\u201019) has significantly disrupted liver transplantation worldwide. Despite significant, collective experience in treating liver transplant recipients with COVID\u201019, there remains a paucity of data to guide the management of transplant candidates with acute COVID\u201019 who require urgent transplantation. We present the case of an otherwise well, 39\u2010year\u2010old female presenting for urgent liver transplantation for acute liver failure secondary to hepatitis B, with concomitant acute, mild COVID\u201019 due to Omicron BA.2. COVID\u201019 antivirals were not administered pre\u2010transplant as the potential risk of hepatotoxicity precipitating further deterioration of liver function was not felt to outweigh the small, potential benefit of antiviral therapy. No effective SARS\u2010CoV\u20102 monoclonal antibodies were available; however, the patient was previously vaccinated against SARS\u2010CoV\u20102 with evidence of anti\u2010spike antibodies at the time of COVID\u201019. Transplantation surgery and recovery were uncomplicated with no progression of COVID\u201019 post\u2010transplant, hospital discharge was at day 14. At 30 days post\u2010transplant the patient had recovered, with normal liver function and SARS\u2010CoV\u20102 was not detectable on nasopharyngeal PCR. While the safety of transplantation of patients with acute COVID\u201019 cannot be assured by a single case, ours highlights the complex decision\u2010making process undertaken and competing priorities that need to be balanced when assessing patients with acute COVID\u201019 who require urgent transplantation.<\/jats:p>","DOI":"10.1111\/tid.13889","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T23:39:26Z","timestamp":1656113966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful liver transplantation for hepatitis B\u2010related acute liver failure in a patient with active COVID\u201019"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-3154","authenticated-orcid":false,"given":"Rachael","family":"Jacob","sequence":"first","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-3168","authenticated-orcid":false,"given":"Ken","family":"Liu","sequence":"additional","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-787X","authenticated-orcid":false,"given":"Tina","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u20100347\u2010z"},{"key":"e_1_2_6_3_1","unstructured":"Assessment of COVID\u201019 status in transplant candidates. The Transplantation Society of Australia and New Zealand. February 2 2022. Accessed May 2 2022.https:\/\/tsanz.com.au\/information\/covid\u201019.htm"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001210"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16582"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.10.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31894\u2010X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(20)30271\u201030275"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31182\u2010X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15458"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118542"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116044"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16894"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116846"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103944"},{"key":"e_1_2_6_16_1","unstructured":"Evusheld long\u2010acting antibody combination retains neutralizing activity against Omicron variant in independent FDA study 2021. AstraZeneca. December 16 2021. Accessed May 14 2022.https:\/\/bit.ly\/3Jluk3d"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13889","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:02:45Z","timestamp":1755514965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,9]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/tid.13889"],"URL":"https:\/\/doi.org\/10.1111\/tid.13889","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2022,7,9]]},"assertion":[{"value":"2022-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13889"}}