{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:08:24Z","timestamp":1773475704144,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we aim to assess short\u2010term allograft outcomes following deceased donor kidney transplantation from severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) lower respiratory tract (LRT) nucleic acid testing (NAT) positive donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September to December 2021, SARS\u2010CoV\u20102 NAT positive organ donors, whose solid abdominal organs were transplanted at our academic medical center were identified. Donors were stratified into having tested positive for SARS\u2010CoV\u20102 in an upper respiratory tract (URT) or LRT sample. For this study, the SARS\u2010CoV\u20102 LRT NAT positive deceased kidney donors and their respective recipients were examined. Donor and recipient demographic data, coronavirus disease 2019 (COVID\u201019)\u2010related history, patient outcomes, as well as postoperative graft function were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen SARS\u2010CoV\u20102 positive deceased donors were identified. Of these, eight were LRT NAT positive and yielded nine kidneys. These allografts were successfully transplanted into vaccinated and unvaccinated recipients. All recipients received standard induction immunosuppression and did not receive any prophylactic therapy for SARS\u2010CoV\u20102. Two recipients had delayed graft function. At 1\u2010month post\u2010transplant, there was no clinical evidence of donor\u2010derived COVID\u201019 or graft loss, and all recipients were free from dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We describe the first case series of SARS\u2010CoV\u20102 LRT NAT positive deceased kidney donors for vaccinated and unvaccinated recipients with excellent short\u2010term allograft outcomes and no clinical evidence of donor\u2010derived COVID\u201019 post\u2010transplantation. Given the increasing prevalence of SARS\u2010CoV\u20102 in the population, utilization of SARS\u2010CoV\u20102 LRT NAT positive deceased donors could be considered an acceptable source of organs for renal transplantation, especially as multi\u2010center experiences and longer\u2010term follow\u2010up emerge.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13890-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13890","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T13:53:36Z","timestamp":1656165216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Short\u2010term kidney transplant outcomes from severe acute respiratory syndrome coronavirus 2 lower respiratory tract positive donors"],"prefix":"10.1111","volume":"24","author":[{"given":"Jorge A.","family":"Sanchez\u2010Vivaldi","sequence":"first","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-899X","authenticated-orcid":false,"given":"Madhukar S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jigesh A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan D.","family":"Salcedo\u2010Betancourt","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine S.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3192","authenticated-orcid":false,"given":"Ricardo M.","family":"La Hoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parsia A.","family":"Vagefi","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16765"},{"key":"e_1_2_14_3_1","first-page":"1","article-title":"Use of organs from SARS\u2010CoV\u20102 infected donors: is it safe?","volume":"8","author":"Kute VB","year":"2021","journal-title":"Contemp Rev Curr Transpl Rep"},{"key":"e_1_2_14_4_1","unstructured":"Organ Procurement and Transplantation Network.Lower respiratory testing of all potential lung donors for SARS\u2010CoV\u20102 now required.2021.https:\/\/unos.org\/news\/sars\u2010cov\u20102\u2010lower\u2010respiratory\u2010testing\u2010potential\u2010lung\u2010donors\u2010may\u201027\/Accessed September 30 2021"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13757"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16823"},{"key":"e_1_2_14_7_1","unstructured":"Organ Procurement and Transplantation Network.Disease transmission advisory 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