{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:53:03Z","timestamp":1760205183042,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although infections are a significant potential complication among patients undergoing left ventricular assist device (LVAD) implantation, standardized surgical infection prophylaxis (SIP) regimens are not well defined. At Montefiore Medical Center, a 4\u2010drug SIP regimen containing fluconazole, ciprofloxacin, rifampin, and vancomycin was previously utilized. In January 2020, the antimicrobial stewardship program implemented a 2\u2010drug SIP regimen of vancomycin and cefazolin to limit exposure to broad\u2010spectrum antibiotics. This study evaluated LVAD\u2010associated infection rates prior to and following the SIP revision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of patients who underwent LVAD implantation from 1\/2018 to 4\/2021 was performed. Infections were classified using the International Society for Heart and Lung Transplantation definitions. Infection rates at 2\u00a0weeks, 30 days, and 90 days post\u2010implantation in the 4\u2010drug SIP regimen (1\/2018\u201012\/2019) and the 2\u2010drug SIP regimen (1\/2020 to 4\/2021) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 71 patients were included. The number of patients with LVAD\u2010associated infections (including surgical site infections) was not significantly different in either SIP group at 2\u00a0weeks (9%\u00a0vs. 4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.64), 30 days (9%\u00a0vs. 11%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.99), or 90 days (19%\u00a0vs. 14%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.75). There was no statistically significant difference in 30 or 90\u2010day mortality. LVAD\u2010associated gram\u2010negative (7%\u00a0vs. 7%; <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.99) and fungal (5%\u00a0vs. 0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.51) infections were uncommon. The most common organism isolated was <jats:italic>Staphylococcus aureus<\/jats:italic>, and the most common type of infection was pneumonia in both SIP groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No significant difference in LVAD\u2010associated infections or infection\u2010related mortality was observed with de\u2010escalation of perioperative antibiotics. Additional studies with larger sample sizes are needed to endorse the findings of this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13900","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T05:29:57Z","timestamp":1656912597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of narrowing perioperative antibiotic prophylaxis for left ventricular assist device implantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-1136","authenticated-orcid":false,"given":"Lauren","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-3124","authenticated-orcid":false,"given":"Rachel","family":"Bartash","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Y.","family":"Minamoto","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsie","family":"Cowman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"},{"name":"Network Performance Group Montefiore Health System  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-051X","authenticated-orcid":false,"given":"Snehal","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasa","family":"Vukelic","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-3922","authenticated-orcid":false,"given":"Daryl U.","family":"Nnani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphenie","family":"Fauvel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.01.036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit536"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14882"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.717"},{"key":"e_1_2_9_8_1","unstructured":"Surgical Site Infection Event (SSI). National Healthcare Safety Network.2021.https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/9pscssicurrent.pdf. Accessed January 7 2022."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119698"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825fa398"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000710"},{"key":"e_1_2_9_12_1","first-page":"1801","article-title":"Impact of antimicrobial selection for prophylaxis of left ventricular assist device surgical infections","volume":"37","author":"Nguyen PT","year":"2021","journal-title":"J Card Surg"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13441"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.03.002"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:39:22Z","timestamp":1692571162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/tid.13900"],"URL":"https:\/\/doi.org\/10.1111\/tid.13900","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13900"}}