{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:45:13Z","timestamp":1781739913820,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK117675"],"award-info":[{"award-number":["R01DK117675"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Improved survival among people with human immunodeficiency virus (HIV) (PWH) has led to increased organ failure, necessitating transplantation. In 2013, the HIV Organ Policy Equity (HOPE) Act was passed, allowing PWH to donate organs to other PWH. No study has assessed organ quality and quantity among a national pool of PWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CFAR Network of Integrated Clinical Systems (CNICS), a multicenter study capturing data on PWH, was used to identify 6504 deaths from 1999 to 2018. Exclusions included cause of death, chronic kidney disease, fibrosis\u20104 score \u2265 3.25, and opportunistic infection at the time of death. Donor quality was defined by HIV viremia and the kidney donor profile index (KDPI). The CDC Wonder database, which contains national death data, permitted the estimation of deaths among PWH nationally from 1999 to 2018. Assuming CNICS was representative of PWH nationally, percentages of potential donors were applied to the CDC Wonder cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within CNICS, there were 3241 (65.9%) potential kidney donors and 3536 (71.9%) potential liver donors from 1999 to 2018. Based on viremia and KDPI, 821 were lower\u2010risk kidney donors (16.7%) and 1206 (24.5%) were lower\u2010risk liver donors. Within CDC Wonder, we identified 12\u00a0048 potential donors from 1999 to 2018. Extrapolating from CNICS to the national cohort suggested 396 kidney donors (792 kidneys) and 433 liver donors annually, with 100 kidney donors (200 kidneys) and 147 livers being lower\u2010risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A substantial number of PWH meet donation criteria, a valuable source of organs for PWH in need of transplants. Our estimates suggest there may be more available organs from PWH than current transplant numbers indicate.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13916-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13916","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T11:39:53Z","timestamp":1659094793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of hope: Analysis of organ quality and availability among deceased HIV\u2010positive donors"],"prefix":"10.1111","volume":"24","author":[{"given":"Christopher","family":"Woods","sequence":"first","affiliation":[{"name":"Division of Transplantation, Department of Surgery University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-0631","authenticated-orcid":false,"given":"Grace","family":"Owens","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"},{"name":"University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-8081","authenticated-orcid":false,"given":"Brittany A.","family":"Shelton","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Sawinski","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Transplantation Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayme E.","family":"Locke","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001014"},{"key":"e_1_2_9_3_1","unstructured":"100 people transplanted thanks to HOPE Act.UNOS. 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Accessed November 15 2021.https:\/\/optn.transplant.hrsa.gov\/resources\/guidance\/kidney\u2010donor\u2010profile\u2010index\u2010kdpi\u2010guide\u2010for\u2010clinicians\/"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21334"},{"key":"e_1_2_9_24_1","unstructured":"World Health Organization.Guidelines for the Prevention Care and Treatment of Persons with Chronic Hepatitis B Infection.World Health Organization;2015."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac620b"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002949"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15672"},{"key":"e_1_2_9_29_1","unstructured":"HOPE Act impact continues at five\u2010year milestone.UNOS. December 16 2020. 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