{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:25:28Z","timestamp":1793424328346,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T00:00:00Z","timestamp":1661644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of urinary tract infections (UTIs) in the first 2 months postrenal transplantation (pRT) is very high. We evaluate the efficacy of asymptomatic bacteriuria (AB) screening and treatment on the incidence of UTI in the first 2 months pRT<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a randomized controlled clinical trial. A urine culture was obtained in all patients on the day of the bladder catheter removal, on week three, and before removal of the ureteral catheter. The intervention group received treatment for AB. The control group did not receive treatment. The primary outcomes were the cumulative incidence of UTI and\/or graft pyelonephritis and the time to the first episode of UTI and\/or graft pyelonephritis<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients were randomized, 40 in each group, and the median follow\u2010up was 63 days (IQR 54\u201370). The average age was 29.8 years and 33.7% (\n                      <jats:italic>n<\/jats:italic>\n                      = 27) were women. The incidences of UTI (\n                      <jats:italic>n<\/jats:italic>\n                      = 10, 25 % vs.\n                      <jats:italic>n<\/jats:italic>\n                      = 4, 10%,\n                      <jats:italic>p<\/jats:italic>\n                      = .07) and pyelonephritis (\n                      <jats:italic>n<\/jats:italic>\n                      = 6, 15% vs.\n                      <jats:italic>n<\/jats:italic>\n                      = 1, 2.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = .04) were greater in the intervention group, as also shown in the survival analysis: UTI (HR2.8, 95% CI 0.8\u20139.1,\n                      <jats:italic>p<\/jats:italic>\n                      = .07) and pyelonephritis (HR 6.5, 95% CI 0.8\u201354.7,\n                      <jats:italic>p<\/jats:italic>\n                      = .08), respectively. The most commonly isolated bacterium was\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 28, 59.5%), and over half were\n                      <jats:italic>E. coli<\/jats:italic>\n                      with extended\u2010spectrum beta\u2010lactamases (\n                      <jats:italic>n<\/jats:italic>\n                      = 15). A major limitation was not obtaining the calculated sample size due to a delay in patient recruitment resulting from the COVID\u201019 pandemic\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Treatment of AB in the first 2 months pRT does not decrease the incidence of UTI or graft pyelonephritis and may actually increase their frequency. Routine treatment of AB during the first months after renal transplantation should not be a standard procedure.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13934-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.13934","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T08:50:08Z","timestamp":1660812608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Treatment of asymptomatic bacteriuria in the first 2 months after kidney transplant: A controlled clinical trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Mendoza Enciso Emmanuel","family":"Antonio","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Centenario Miguel Hidalgo  Aguascalientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barajas Garc\u00eda Carolina","family":"Cassandra","sequence":"additional","affiliation":[{"name":"Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodriguez Jimenez Dante","family":"Emiliano","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Centenario Miguel Hidalgo  Aguascalientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortiz Lopez Margarita","family":"Guadalupe","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Centenario Miguel Hidalgo  Aguascalientes 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