{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:53:17Z","timestamp":1760205197203,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current situation, challenges, and opportunities related to antimicrobial stewardship for solid organ transplantations (SOTs) patients in Japan are not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched English and Japanese literature using Pubmed and Ichushi\u2010Web (the Japanese medical literature search system provided by the Japan Medical Abstract Society) with relevant keywords including solid organ transplant, antimicrobial stewardship, and Japan. Hand searches of the references from the retrieved literature, including conference proceedings of The Japanese Association for Infectious Diseases, were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Japanese National Action Plan for antimicrobial resistance has brought attention to the importance of antimicrobial stewardship programs (ASPs) in Japan. According to national surveillance, the proportion of methicillin resistance among <jats:italic>Staphylococcus aureus<\/jats:italic> was 48%, while the proportion of vancomycin\u2010resistance among <jats:italic>Enterococcus<\/jats:italic> faecium was 1.5% in 2019. Resistance against imipenem in <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> in 2019 were 0.1% and 0.2%, respectively. Exploration of SOT\u2010specific data on antimicrobial usage and drug resistance are warranted. A large questionnaire survey revealed a low proportion of hospitals with &gt;500 beds implementing ASP toward immunocompromised patients. While the annual number of SOT in Japan has increased, the implementation of SOT\u2010specific ASP varies among institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A coordinated ASP and exploration of the burden of antimicrobial resistance are needed for SOT patients in Japan. Promoting both intrainstitutional and interinstitutional collaboration is vital to the advancement of SOT\u2010specific ASP in Japan.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13939-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13939","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T07:04:42Z","timestamp":1666076682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Japan perspective on antimicrobial stewardship and solid organ transplantation"],"prefix":"10.1111","volume":"24","author":[{"given":"Satoshi","family":"Kitaura","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The University of Tokyo Hospital  Tokyo Japan"},{"name":"The National Institute of Infectious Diseases  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-3862","authenticated-orcid":false,"given":"Kazuaki","family":"Jindai","sequence":"additional","affiliation":[{"name":"Department of Virology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Department of Healthcare Epidemiology Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-9096","authenticated-orcid":false,"given":"Koh","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"volume-title":"Fact Book 2021 on Organ Transplantation in Japan","year":"2021","author":"The Japan Society for Transplantation","key":"e_1_2_9_2_1"},{"unstructured":"WHO\u2010ONT Collaboration.Global observatory on donation and transplantation (GODT) data.2022. Accessed March 24 2022.http:\/\/www.transplant\u2010observatory.org\/","key":"e_1_2_9_3_1"},{"unstructured":"Statistics Bureau Ministry of Internal Affairs and Communications Japan. Statistical handbook Of Japan.2021. Accessed March 17 2022.https:\/\/www.stat.go.jp\/english\/data\/handbook\/index.html","key":"e_1_2_9_4_1"},{"volume-title":"National Action Plan on Antimicrobial Resistance (AMR)","year":"2016","author":"The Government of Japan","key":"e_1_2_9_5_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.35772\/ghm.2019.01017"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1016\/j.jiac.2018.11.001"},{"volume-title":"Fact Book 2020 on Organ Transplantation in Japan","year":"2021","author":"The Japan Society for Transplantation","key":"e_1_2_9_8_1"},{"unstructured":"United States Census Bureau.Annual estimates of the resident population for the United States Regions States District of Columbia and Puerto Rico: April 1 2020 to July 1 2021 (NST\u2010EST2021\u2010POP).2022. Accessed June 16 2022.https:\/\/www2.census.gov\/programs\u2010surveys\/popest\/tables\/2020\u20102021\/state\/totals\/NST\u2010EST2021\u2010POP.xlsx","key":"e_1_2_9_9_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.11386\/jst.56.3_217"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1111\/ctr.13552"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1093\/ofid\/ofaa124"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/j.ijid.2019.05.001"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1053\/j.ajkd.2021.01.002"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.4009\/jsdt.54.611"},{"unstructured":"United States Census Bureau.Cumulative estimates of resident population change for the United States Regions States and Puerto Rico: April 1 2010 to July 1 2019 (NST\u2010EST2019\u201002).2021. Accessed April 7 2022.https:\/\/www2.census.gov\/programs\u2010surveys\/popest\/tables\/2010\u20102019\/state\/totals\/nst\u2010est2019\u201001.xlsx","key":"e_1_2_9_16_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.1016\/s1473\u20103099(18)30566\u20108"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.3390\/antibiotics10111293"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.3390\/antibiotics10101189"},{"doi-asserted-by":"publisher","key":"e_1_2_9_20_1","DOI":"10.7883\/yoken.jjid.2020.499"},{"unstructured":"National Center for Global Health and Medicine AMR Clinical Reference Center. Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J\u2010SIPHE) annual report 2020. Accessed April 1 2022.https:\/\/j\u2010siphe.ncgm.go.jp\/files\/JSIPHE_AnnualReport_2020en.pdf","key":"e_1_2_9_21_1"},{"unstructured":"Ministry of Health Labour and Welfare.NDB open data. Accessed April 1 2022.https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000177182.html","key":"e_1_2_9_22_1"},{"unstructured":"National Center for Global Health and Medicine AMR Clinical Reference Center.Surveillance of antibiotic sales in Japan. February 25 2022. Accessed 1 April 2022.https:\/\/amrcrc.ncgm.go.jp\/surveillance\/020\/20200813162318.html","key":"e_1_2_9_23_1"},{"unstructured":"The AMR One Health Surveillance Committee.Nippon AMR one health report (NAOR).2020. Accessed April 1 2022.https:\/\/www.mhlw.go.jp\/content\/10900000\/000885373.pdf","key":"e_1_2_9_24_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_25_1","DOI":"10.1007\/s10096\u2010018\u20103333\u20104"},{"doi-asserted-by":"publisher","key":"e_1_2_9_26_1","DOI":"10.1056\/NEJMra064928"},{"doi-asserted-by":"publisher","key":"e_1_2_9_27_1","DOI":"10.1111\/ajt.16743"},{"unstructured":"The University of Tokyo Hospital.Number of beds and facility standards [in Japanese]. 2022. Accessed June 16 2022.https:\/\/www.h.u\u2010tokyo.ac.jp\/about\/shisetsu\/","key":"e_1_2_9_28_1"},{"unstructured":"The University of Tokyo Hospital.Number of patients [in Japanese]. 2022. Accessed June 16 2022.https:\/\/www.h.u\u2010tokyo.ac.jp\/about\/kanjasu\/","key":"e_1_2_9_29_1"},{"unstructured":"The Japanese Association for Infectious Diseases. Specialists (\u201cSenmonni Meibo\u201d).2022. Accessed April 7 2022.https:\/\/www.kansensho.or.jp\/modules\/senmoni\/index.php?content_id=29","key":"e_1_2_9_30_1"},{"unstructured":"Portal Sites of Official Statistics of Japan. \u201cPopulation estimates: December 2021 confirmed May 2022 estimates\u201d [In Japanese]. Accessed June 16 2022.https:\/\/www.e\u2010stat.go.jp\/stat\u2010search\/file\u2010download?statInfId=000032199335&fileKind=0","key":"e_1_2_9_31_1"},{"unstructured":"American Board of Internal Medicine.Number of certificates issued \u2013 all candidates. 2021. Accessed March 17 2022.https:\/\/www.abim.org\/Media\/vaqdilmh\/1_candidates\u2010certified\u2010all\u2010candidates\u2010050121.pdf","key":"e_1_2_9_32_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_33_1","DOI":"10.1016\/j.jiac.2019.05.012"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:40:39Z","timestamp":1692571239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/tid.13939"],"URL":"https:\/\/doi.org\/10.1111\/tid.13939","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13939"}}