{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:02:13Z","timestamp":1771995733344,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The best approach to tuberculosis (TB) treatment in transplanted patients is still unknown. Current guidelines are based on evidence either extrapolated from other populations or observational. Rifampin\u2010containing regimens have strong pharmacokinetic interactions with immunosuppressive regimens, with high rates of organ dysfunction and \u223c20% mortality. This report describes the results obtained using non\u2010rifampin\u2010containing regimens to treat confirmed TB in adult patients with kidney\/kidney\u2013pancreas transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective data analysis from confirmed TB cases in adult kidney\/kidney\u2013pancreas transplant recipients (2006\u20132019), treated \u201cde novo\u201d with non\u2010rifampin\u2010containing regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven patients had confirmed TB. Thirty patients were treated \u201cde novo\u201d with non\u2010rifampin\u2010containing regimens. These patients\u2019 mean age was 49.24 (\u00b111.50) years. Induction immunosuppression was used in 22 patients. Maintenance immunosuppression was tacrolimus\u2013mycophenolate\u2013steroids in 13 (43%), sirolimus\u2013mycophenolate\u2013steroids in 6 (20%), and other immunosuppressive regimens in 11 (36%). Belatacept was used in four patients. TB localizations: pulmonary 43%; disseminated 23%; extrapulmonary 33%. Twenty\u2010seven (90%) patients completed treatment with isoniazid, ethambutol, and levofloxacin (12 months, 23; 9 months, 3; 6 months, 1); 12 of these patients also received pyrazinamide for the first 2\u00a0months and were cured with functioning grafts. One patient (3%) lost the graft while on treatment. Two patients (7%) died while on TB treatment. Median (range) follow\u2010up after completion of TB treatment was 32 (8\u2013150) months. No TB relapses were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results with non\u2010rifampin\u2010containing TB treatments in this case series were better (in terms of mortality and graft dysfunction) than those previously described with rifampin\u2010containing regimens in transplanted patients.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13949-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13949","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T13:23:46Z","timestamp":1671024226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tuberculosis treatment without rifampin in kidney\/kidney\u2013pancreas transplantation: A case series report"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-6156","authenticated-orcid":false,"given":"Marcelo Victor","family":"Radisic","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Instituto de Trasplante y Alta Complejidad (ITAC)  Autonomous City of Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-2163","authenticated-orcid":false,"given":"Natalia Rosana","family":"Pujato","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto de Trasplante y Alta Complejidad (ITAC)  Autonomous City of Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-3708","authenticated-orcid":false,"given":"Pablo Martin","family":"Bravo","sequence":"additional","affiliation":[{"name":"Infectious 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