{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:22:51Z","timestamp":1778800971528,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08\u00a0HL136888"],"award-info":[{"award-number":["K08\u00a0HL136888"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reports on outcomes following severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in lung transplant recipients remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center, observational study of outcomes in lung transplant recipients diagnosed with SARS\u2010CoV\u20102 between 5\/1\/2020 and 3\/15\/2022 that were followed for a median of 123 days. We analyzed changes in spirometry, acute lung allograft dysfunction (ALAD) incidence, hospitalization, mechanical ventilation needs, secondary infection, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our cohort of 336 patients, 103 developed coronavirus disease (COVID) (27 pre\u2010Delta, 20 Delta, and 56 Omicron\u2010era). Twenty\u2010five patients (24%) required hospitalization and 10 patients ultimately died (10%). Among 85 survivors who completed ambulatory spirometry, COVID\u201019 did not alter change in forced expiratory volume in 1\u00a0s (FEV<jats:sub>1<\/jats:sub>) or forced vital capacity (FVC) over time compared to the preceding 6 months. The pre\u2010COVID FEV<jats:sub>1<\/jats:sub>change was \u22120.05\u00a0ml\/day (IQR \u22120.50 to 0.60) compared to \u22120.20\u00a0ml\/day (IQR \u22121.40 to 0.70) post\u2010COVID (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.16). The pre\u2010COVID change in FVC was 0.20\u00a0ml\/day (IQR \u22120.60 to 0.70) compared to 0.05\u00a0ml\/day (IQR \u22121.00 to 1.10) post\u2010COVID (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.76). Although the cohort overall had stable lung function, 33 patients (39%) developed ALAD or accelerated chronic lung allograft dysfunction (FEV<jats:sub>1<\/jats:sub>decline &gt;10% from pre\u2010COVID baseline). Nine patients (35%) with ALAD recovered lung function. Within 3 months of acute COVID infection, 18 patients (17%) developed secondary infections, the majority being bacterial pneumonia. Finally, vaccination with at least two doses of mRNA vaccine was not associated with improved outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study describes the natural history of SARS\u2010CoV\u20102 infection in a large cohort of lung transplant recipients. Although one third of patients develop ALAD requiring augmented immunosuppression, infection with SARS\u2010CoV\u20102 is not associated with worsening lung function.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid13967-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13967","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T06:13:27Z","timestamp":1666419207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical course of SARS\u2010CoV\u20102 infection and recovery in lung transplant recipients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-7228","authenticated-orcid":false,"given":"Anil J.","family":"Trindade","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Allergy Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-8691","authenticated-orcid":false,"given":"Kaitlyn C.","family":"Chapin","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-0029","authenticated-orcid":false,"given":"Whitney D.","family":"Gannon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-8520","authenticated-orcid":false,"given":"Haley","family":"Hoy","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-1103","authenticated-orcid":false,"given":"Caitlin T.","family":"Demarest","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Lambright","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Vanderbilt University Medical Center Nashville Tennessee 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