{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:12:16Z","timestamp":1781651536319,"version":"3.54.5"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infection is a significant risk factor that impacts for perioperative morbidity and mortality in liver transplantation (LTx) patients and is difficult to evaluate quantitatively in the early posttransplantation period. Thus, a biomarker to assess the risk of infection and the prognosis of the recipient is highly desirable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 128 consecutive patients with end\u2010stage liver diseases undergoing LTx between January 1, 2020 and December 31, 2021, at the First Affiliated Hospital of Zhejiang University School of Medicine, were screened retrospectively. Graft preservation fluid and blood samples were collected for culture, and other perioperative laboratory examination results were recorded, for assessment of infection status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a follow\u2010up period of 30 days, the survival rate among the 128 LTx recipients was 94.5%. Multivariable regression analysis showed that the logarithmically transformed neutrophil\u2010to\u2010lymphocyte ratio (NLR) (HR\u00a0=\u00a03.548, 95% CI: ; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.041) on post\u2010LTx day 1 and graft preservation fluid culture positivity (HR\u00a0=\u00a012.032, 95% CI: ; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006) were independent predictive factors for early prognosis after LTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive graft preservation fluid culture and the logarithmically transformed NLR on post\u2010LTx day 1 were independent predictive factors for early prognosis after LTx. The logarithmically transformed NLR could provide an earlier indication than culture results in clinical practice.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14002-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14002","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T09:05:24Z","timestamp":1671699924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Infection evaluation in the early period after liver transplantation: A single\u2010center exploration"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-3404","authenticated-orcid":false,"given":"Zhen\u2010Hua","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Bo","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Shan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Nursing, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Li","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Bo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Liver Transplantation Center, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Key Lab of Combined Multi\u2010Organ Transplantation of The Ministry of Health, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12467"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz591"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-021-04668-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2021.01.032"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i34.6261"}],"container-title":["Transplant Infectious 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