{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:00:40Z","timestamp":1773687640962,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The utilization of non\u2010lung organs from deceased donors with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) at the time of donation can be lifesaving, although the safety of this policy must be assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a nationwide, prospective study, reporting the experience on the utilization of non\u2010lung organs from SARS\u2010CoV\u20102\u2010positive donors between December 15, 2020 and May 31, 2022 in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 69 patients received a solid organ transplant (41 kidney, 18 liver, 8 heart, and 2 combined liver\u2013kidney) obtained from 32 donors with a positive SARS\u2010CoV\u20102 PCR at the time of donation (four of them with a cycle threshold value &lt;30). All recipients tested negative for SARS\u2010CoV\u20102 and were free of coronavirus disease 2019 (COVID\u201019) symptoms prior to transplantation. Nasopharyngeal swab turned positive for SARS\u2010CoV\u20102 PCR in 4 (5.8%) recipients at 3, 8, 11, and 20 days after transplantation, though evidence did not support a donor\u2010derived COVID\u201019. Four kidney recipients lost their grafts and two patients died: one heart recipient due to cardiogenic shock and one combined liver\u2013kidney recipient due to lung hypertension and right heart failure. Graft losses and patient deaths were deemed unrelated to the donor SARS\u2010CoV\u20102 status by the treating teams. No other adverse reactions were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This preliminary experience supports the safety of the use of organs other than lungs from SARS\u2010CoV\u20102 PCR\u2010positive donors, in alignment with previous series. However, the impact of SARS\u2010CoV\u20102 infection upon organ quality should be established in future research.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14008-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14008","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:48:20Z","timestamp":1674197300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transplantation of organs from SARS\u2010CoV\u20102\u2010positive donors: Preliminary experience from Spain"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-8645","authenticated-orcid":false,"given":"Patricia","family":"Montiel Villalonga","sequence":"first","affiliation":[{"name":"Organizaci\u00f3n Nacional de Trasplantes  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itz\u00edar","family":"Mart\u00ednez\u2010Alpuente","sequence":"additional","affiliation":[{"name":"Organizaci\u00f3n Nacional de Trasplantes  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12) Department of Medicine Universidad Complutense  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n 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