{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:53:29Z","timestamp":1790848409309,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Decisions to transplant organs from severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) nucleic acid test\u2010positive (NAT+) donors must balance risk of donor\u2010derived transmission events (DDTE) with the scarcity of available organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Organ Procurement and Transplantation Network (OPTN) data were used to compare organ utilization and recipient outcomes between SARS\u2010CoV\u20102 NAT+ and NAT\u2013 donors. NAT+ was defined by either a positive upper or lower respiratory tract (LRT) sample within 21 days of procurement. Potential DDTE were adjudicated by OPTN Disease Transmission Advisory Committee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From May 27, 2021 (date of OTPN policy for required LRT testing of lung donors) to January 31, 2022, organs were recovered from 617 NAT+ donors from all OPTN regions and 53 of 57 (93%) organ procurement organizations. NAT+ donors were younger and had higher organ quality scores for kidney and liver. Organ utilization was lower for NAT+ donors compared to NAT\u2013 donors. A total of 1241 organs (776 kidneys, 316 livers, 106 hearts, 22 lungs, and 21 other) were transplanted from 514 NAT+ donors compared to 21\u00a0946 organs from 8853 NAT\u2013 donors. Medical urgency was lower for recipients of NAT+ liver and heart transplants. The median waitlist time was longer for liver recipients of NAT+ donors. The match run sequence number for final acceptor was higher for NAT+ donors for all organ types. Outcomes for hospital length of stay, 30\u2010day mortality, and 30\u2010day graft loss were similar for all organ types. No SARS\u2010CoV\u20102 DDTE occurred in this interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transplantation of SARS\u2010CoV\u20102 NAT+ donor organs appears safe for short\u2010term outcomes of death and graft loss and ameliorates the organ shortage. Further study is required to assure comparable longer term outcomes.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14013-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14013","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T06:19:54Z","timestamp":1674627594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Transplant of organs from donors with positive SARS\u2010CoV\u20102 nucleic acid testing: A report from the organ procurement and transplantation network ad hoc disease transmission advisory committee"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-6832","authenticated-orcid":false,"given":"Jason D.","family":"Goldman","sequence":"first","affiliation":[{"name":"Organ Transplant and Liver Center Swedish Medical Center  Seattle Washington USA"},{"name":"Division of Allergy and Infectious Diseases University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-2444","authenticated-orcid":false,"given":"Stephanie M.","family":"Pouch","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta  Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Woolley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Booker","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney T.","family":"Jett","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole","family":"Fox","sequence":"additional","affiliation":[{"name":"United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-2629","authenticated-orcid":false,"given":"Gerald J.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chak\u2010Sum","family":"Ho","sequence":"additional","affiliation":[{"name":"Gift of Hope Organ and Tissue Donor Network  Itasca Illinois USA"},{"name":"College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kittleson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1860-3446","authenticated-orcid":false,"given":"Dong Heun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas Health Science Center San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Marboe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University New York  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-4835","authenticated-orcid":false,"given":"Gary","family":"Marklin","sequence":"additional","affiliation":[{"name":"Mid\u2010America Transplant  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"Division of Public Health Infectious Diseases and Occupational Medicine and the William J. von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Taimur","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen S.","family":"Te","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Anesi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty T.","family":"Sellers","sequence":"additional","affiliation":[{"name":"DCI Donor Services, Inc.  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-7228","authenticated-orcid":false,"given":"Anil J.","family":"Trindade","sequence":"additional","affiliation":[{"name":"Division of Allergy Pulmonary and Critical Care Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Patrick","family":"Wood","sequence":"additional","affiliation":[{"name":"LifeGift Organ Donation Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Zaffiri","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn E.","family":"Levi","sequence":"additional","affiliation":[{"name":"Division of Transplantation Health Systems Bureau Health Resources and Services Administration  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Klassen","sequence":"additional","affiliation":[{"name":"Office of the Chief Medical Officer United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-0544","authenticated-orcid":false,"given":"Marian G.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Pittsburg  Pittsburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3192","authenticated-orcid":false,"given":"Ricardo M.","family":"La Hoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Geographic Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-5221","authenticated-orcid":false,"given":"Lara","family":"Danziger\u2010Isakov","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31040\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003391"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004158"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00200\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15941"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1097"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17036"},{"key":"e_1_2_11_9_1","unstructured":"Disease Transmission Advisory Committee.Summary of current evidence and information\u2014donor SARS\u2010CoV\u20102 testing & organ recovery from donors with a history of COVID\u201019. Accessed February 28 2021.https:\/\/optn.transplant.hrsa.gov\/media\/kkhnlwah\/sars\u2010cov\u20102\u2010summary\u2010of\u2010evidence.pdf"},{"key":"e_1_2_11_10_1","unstructured":"National Health Service Blood and Transplant.SARS\u2010CoV\u20102 assessment and screening in organ donors and recipients\u2010POL304.2020. Accessed July 27 2022.https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/20342\/pol304.pdf"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16000"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15969"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15832"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1196"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003744"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2011400"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8120626"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005542\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16532"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16576"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac221"},{"key":"e_1_2_11_22_1","unstructured":"OPTN Ad Hoc Disease Transmission Advisory Committee.Notice of OPTN emergency policy change: lower respiratory SARS\u2010CoV\u20102 testing for lung donors. Accessed August 10 2022.https:\/\/optn.transplant.hrsa.gov\/media\/4576\/policy_notice_lunglowerrespiratorytesting_20210426.pdf"},{"key":"e_1_2_11_23_1","unstructured":"OPTN Ad Hoc Disease Transmission Advisory Committee.Retrospective public comment for emergency policy. Require lower respiratory SARS\u2010CoV\u20102 testing for lung donors. Accessed August 9 2022.https:\/\/optn.transplant.hrsa.gov\/media\/4785\/minibrief_lower\u2010respiratory\u2010sars\u2010cov\u20102\u2010testing\u2010for\u2010lung\u2010donors.pdf"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003609"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13503"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15997"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16548"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16905"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16765"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13890"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16823"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13757"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004091"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17126"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17145"},{"key":"e_1_2_11_36_1","unstructured":"OPTN Ad Hoc Disease Transmission Advisory Committee.Notice of OPTN emergency policy change: lower respiratory SARS\u2010CoV\u20102 testing for lung donors. Accessed September 15 2022.https:\/\/optn.transplant.hrsa.gov\/media\/5e5eqf4a\/policy\u2010notice_dtac_lrt.pdf"},{"key":"e_1_2_11_37_1","unstructured":"OPTN: Organ Procurement and Transplantation Network Policies.Policy 15: identification of transmissible diseases. Accessed August 9 2022.https:\/\/optn.transplant.hrsa.gov\/media\/eavh5bf3\/optn_policies.pdf"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16178"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.06.018"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004074"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16577"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003528"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.14013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T20:57:44Z","timestamp":1692305864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/tid.14013"],"URL":"https:\/\/doi.org\/10.1111\/tid.14013","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"2022-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14013"}}