{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:35:21Z","timestamp":1753878921475,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated whether donor\u2010recipient mismatch involving one or more cytomegalovirus (CMV) immunodominant (ID) human leukocyte antigen (HLA)\u2010I alleles may impact on the degree of CMV pp65\/immediate\u2010early 1 (IE\u20101) T\u2010cell reconstitution and the incidence of CMV DNAemia in patients undergoing unmanipulated haploidentical hematopoietic stem cell transplantation with high\u2010dose posttransplant cyclophosphamide (PT\/Cy\u2010haplo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter observational study including 106 consecutive adult PT\/Cy\u2010haplo patients (34 CMV ID HLA\u2010I matched and 72 mismatched). A real\u2010time PCR was used for plasma CMV DNA load monitoring. Enumeration of CMV\u2010specific (pp65\/IE\u20101) interferon (IFN)\u2010\u03b3\u2010producing T cells from several patients was performed by flow cytometry by days +30, +60, +90 and +180 after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of CMV DNAemia, clinically significant CMV DNAemia episodes (cs\u2010CMVi), and recurrent CMV DNAemia was comparable across CMV ID HLA\u2010I matched and mismatched patients (71.8%\u00a0vs. 80.9%, <jats:italic>p<\/jats:italic> = .95; 40.7%\u00a0vs. 44.2%, <jats:italic>p<\/jats:italic> = .85; 16.4%\u00a0vs. 28.1%; <jats:italic>p<\/jats:italic> = .43, respectively). The percentage of patients exhibiting detectable CMV\u2010specific IFN\u2010\u03b3\u2010producing T\u2010cell responses (either CD8<jats:sup>+<\/jats:sup> or CD4<jats:sup>+<\/jats:sup>) was similar across groups; nevertheless, significantly higher CMV\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell counts were enumerated in the CMV ID HLA\u2010I matched compared to mismatched patients by day +60 (<jats:italic>p<\/jats:italic> = .04) and +180 (<jats:italic>p<\/jats:italic> = .016) after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CMV ID HLA\u2010I matching may impact on the magnitude of CMV\u2010pp65\/IE\u20101\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell reconstitution; yet, this effect seemed not to have an impact on the incidence of initial, recurrent CMV DNAemia, or cs\u2010CMVi.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14065-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14065","type":"journal-article","created":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T18:19:38Z","timestamp":1682878778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of cytomegalovirus immunodominant HLA\u2010I donor\u2013recipient matching on the incidence and features of virus DNAemia and virus\u2010specific T\u2010cell immune reconstitution in unmanipulated haploidentical hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"25","author":[{"given":"Dixie","family":"Huntley","sequence":"first","affiliation":[{"name":"Microbiology Service INCLIVA Research Institute Hospital Cl\u00ednico Universitario  Valencia 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Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Remigia","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA Research Institute  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Hern\u00e1ndez\u2010Boluda","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario INCLIVA Research Institute  Valencia Spain"},{"name":"Department of Medicine School of Medicine University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hematology Service Hospital Cl\u00ednico Universitario  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Gago","sequence":"additional","affiliation":[{"name":"Hematology 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