{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:56:20Z","timestamp":1790826980483,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) is a frequent infectious complication following solid organ transplantation (SOT). Considering significant differences in healthcare systems, a systematic review was conducted to describe the epidemiology, management, and burden of CMV post\u2010SOT in selected countries outside of Europe and North America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Embase, and Cochrane databases were searched for observational studies in SOT recipients across 15 countries in the regions of Asia, Pacific, and Latin America (search period: January 1, 2011 to September 17, 2021). Outcomes included incidence of CMV infection\/disease, recurrence, risk factors, CMV\u2010related mortality, treatment patterns and guidelines, refractory and\/or resistant CMV, patient\u2010reported outcomes, and economic burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2708 studies identified, 49 were eligible (<jats:italic>n<\/jats:italic>\u00a0=\u00a043\/49; 87.8% in adults; <jats:italic>n<\/jats:italic>\u00a0=\u00a034\/49, 69.4% in kidney recipients). Across studies, selection of CMV preventive strategy was based on CMV serostatus. Overall, rates of CMV infection (within 1 year) and CMV disease post\u2010SOT were respectively, 10.3%\u201363.2% (9\u00a0studies) and 0%\u201319.0% (17 studies). Recurrence occurred in 35.4%\u201341.0% cases (3 studies) and up to 5.3% recipients died of CMV\u2010associated causes (11 studies). Conventional treatments for CMV infection\/disease included ganciclovir (GCV) or valganciclovir. Up to 4.4% patients were resistant to treatment (3 studies); no studies reported on refractory CMV. Treatment\u2010related adverse events with GCV included neutropenia (2%\u201329%), anemia (13%\u201348%), leukopenia (11%\u201337%), and thrombocytopenia (13%\u201324%). Data on economic burden were scarce.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14070-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outside of North America and Europe, rates of CMV infection\/disease post\u2010SOT are highly variable and CMV recurrence is frequent. CMV resistance and treatment\u2010associated adverse events, including myelosuppression, highlight unmet needs with conventional therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14070","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T10:53:25Z","timestamp":1685530405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-323X","authenticated-orcid":false,"given":"Helio Tedesco","family":"Silva Junior","sequence":"first","affiliation":[{"name":"Division of Nephrology, Hospital do Rim, Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaman","family":"Tokat","sequence":"additional","affiliation":[{"name":"International Liver Center &amp; Acibadem Healthcare Hospitals  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhen","family":"Cai","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Takeda Biopharmaceuticals India Pvt. 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