{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:11:34Z","timestamp":1789071094988,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) is a common cause of morbidity after allogeneic haematopoietic cell transplantation (alloHCT). Pre\u2010emptive therapy (PET) with valganciclovir (VGC) is associated with haematological toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included alloHCT patients from 2018 to 2021 where letermovir (LTV) was used for CMV PET because of cytopenias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients were included. Six received VGC prior to LTV. VGC was commenced at median d42, given for median 40 days. LTV was commenced at median d90, given for median 54 days. At commencement of antiviral, CMV viral load was higher for VGC at 3.7 log<jats:sub>10<\/jats:sub> IU\/mL, compared to LTV at 2.9 log<jats:sub>10<\/jats:sub> IU\/mL. Viral load reduction occurred at 0.18 log<jats:sub>10<\/jats:sub> IU\/mL per week for VGC, compared to 0.17 log<jats:sub>10<\/jats:sub> IU\/mL per week for LTV. There was no clinically significant CMV viremia after stopping LTV. Cytopenias improved on LTV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LTV was effective in controlling CMV viremia when it was given at a lower starting CMV viral load and later post alloHCT than VGC. Further study is required of LTV as upfront PET following alloHCT.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14147-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14147","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T15:58:24Z","timestamp":1694102304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Letermovir for pre\u2010emptive cytomegalovirus therapy after allogeneic hematopoietic cell transplantation"],"prefix":"10.1111","volume":"25","author":[{"given":"Raena","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital and PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Purtill","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital and PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Cooney","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital and PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cannell","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital and PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital and PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tandy\u2010Sue","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fiona Stanley Hospital  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fiona Stanley Hospital  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-0421","authenticated-orcid":false,"given":"Peter","family":"Boan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fiona Stanley Hospital  Murdoch Australia"},{"name":"Department of Microbiology PathWest Laboratory Medicine WA  Murdoch Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.05.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001418"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1159"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1713"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105422"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13502"},{"key":"e_1_2_8_9_1","article-title":"Letermovir for prophylaxis and pre\u2010emptive therapy of cytomegalovirus infection in paediatric allogeneic haematopoietic cell transplant patients","author":"Korholz KF","year":"2022","journal-title":"Paediatr Drugs"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13687"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15764"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03990-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002886"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15135"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002785"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-143560"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1112925.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_8_19_1","unstructured":"National Health and Medical Research Council.National statement on ethical conduct in human research.2018. Accessed 19 Jan 2023.https:\/\/www.nhmrc.gov.au\/about\u2010us\/publications\/national\u2010statement\u2010ethical\u2010conduct\u2010human\u2010research\u20102007\u2010updated\u20102018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13786"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12225"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.12.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12965"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4016-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02337-18"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:56:05Z","timestamp":1703260565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/tid.14147"],"URL":"https:\/\/doi.org\/10.1111\/tid.14147","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,7]]},"assertion":[{"value":"2023-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14147"}}