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Indeed, infectious complications represent the key determinant of non\u2010relapse mortality after CAR\u2010T cells. The temporal distribution of these risk factors shapes different infection patterns early versus late post\u2010CAR\u2010T\u2010cell infusion. Furthermore, due to the expression of their targets on B lineage cells at different stages of differentiation, CD19, and B\u2010cell maturation antigen (BCMA) CAR\u2010T cells induce distinct immune deficits that could require different prevention strategies. Infection incidence is the highest during the first month post\u2010infusion and subsequently decreases thereafter. However, infections remain relatively common even a year after infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bacterial infections predominate early after CD19, while a more equal distribution between bacterial and viral causes is seen after BCMA CAR\u2010T\u2010cell therapy, and fungal infections are universally rare. Cytomegalovirus (CMV) and other herpesviruses are increasingly breported, but whether routine monitoring is warranted for all, or a subgroup of patients, remains to be determined. Clinical practices vary substantially between centers, and many areas of uncertainty remain, including CMV monitoring, antibacterial and antifungal prophylaxis and duration, use of immunoglobulin replacement therapy, and timing of vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Risk stratification tools are available and may help distinguish between infectious and non\u2010infectious causes of fever post\u2010infusion and predict severe infections. These tools need prospective validation, and their integration in clinical practice needs to be systematically studied.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14157-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14157","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:31:37Z","timestamp":1696393897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Infections after chimeric antigen receptor (CAR)\u2010T\u2010cell therapy for hematologic malignancies"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8019-3073","authenticated-orcid":false,"given":"Eleftheria","family":"Kampouri","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Infectious Diseases Service Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Little","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Rejeski","sequence":"additional","affiliation":[{"name":"Department of Medicine III\u2014Hematology\/Oncology LMU University Hospital, LMU Munich Munich Germany"},{"name":"German Cancer Consortium (DKTK) Munich site, and German Cancer Research Center  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-0943","authenticated-orcid":false,"given":"Oriol","family":"Manuel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah P.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Divisions of Hematology\/Oncology and Infectious Diseases Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Hill","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"National Institutes of Health (NIH) National Cancer Institute.CAR T Cells: Engineering Patients\u2019 Immune Cells to Treat Their Cancers. 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