{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:12:29Z","timestamp":1756897949990,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Hepatosplenic T\u2010cell lymphoma (HSTCL) is an uncommon and highly aggressive subtype of peripheral T\u2010cell lymphoma characterized by liver, spleen, and bone marrow involvement. Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only curative treatment for HSTCL, but it carries a significant risk of relapse. Cytomegalovirus (CMV) reactivation is a frequent complication after alloHSCT, particularly in patients undergoing lymphocyte\u2010toxic therapies. A 27\u2010year\u2010old man diagnosed with HSTCL underwent an alloHSCT with active disease after six lines of therapy. A CMV reactivation was successfully treated with foscarnet. A sudden reappearance of symptomatic lymphocytosis (15,550\/\u03bcL) by day +20, prior to engraftment, raised suspicion of disease progression. A comprehensive diagnostic work\u2010up revealed an oligoclonal expansion of donor lymphocytes along with complete donor chimerism, leading to an alternative diagnosis of a CMV\u2010driven T\u2010cell expansion. This was confirmed by an in vitro assay testing T\u2010cell specificity against CMV. The patient achieved both complete response and complete donor chimerism despite persisting lymphocytosis, but ultimately relapsed. This case highlights the importance of diagnostic tools in understanding disease progression and guiding treatment decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14170","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T09:53:35Z","timestamp":1697190815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytomegalovirus\u2010driven early\u2010onset lymphocytosis in hematopoietic allogeneic transplant mimicking a T\u2010cell lymphoma progression"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-527X","authenticated-orcid":false,"given":"Juan","family":"Eir\u00eds","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia Hospital Universitari I Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-3648","authenticated-orcid":false,"given":"Crist\u00f3bal","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS\u2010La Fe)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5978-2578","authenticated-orcid":false,"given":"Manuel","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia Hospital Universitari I Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Servicio de Hematolog\u00eda y Hemoterapia Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS\u2010La Fe)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017","author":"Swerdlow SH","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.280"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112666"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201003\u2010631853"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0921-6"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:36:01Z","timestamp":1721198161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/tid.14170"],"URL":"https:\/\/doi.org\/10.1111\/tid.14170","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14170"}}