{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:25Z","timestamp":1753879585044,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["564\/1\u2010000\u201000\/564\u201020\u2010063"],"award-info":[{"award-number":["564\/1\u2010000\u201000\/564\u201020\u2010063"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Infectious complications of autologous hematopoietic stem cell transplantation (AHSCT) are the most common adverse effects of the therapy, resulting in prolonged hospitalization and deterioration of patient well\u2010being. Identifying predictors of these complications is essential for improving patient outcomes and guiding clinical management. This study aimed to examine thrombospondin\u20101 (THBS\u20101) serum levels as a potential biomarker for predicting bacteremia in AHSCT recipients. Blood samples were collected from 30 patients undergoing BeEAM\/BEAM (bendamustine\/carmustine, etoposide, cytarabine, melphalan) conditioning regimen at subsequent time points during AHSCT. THBS\u20101 levels were quantified using ELISA kits. Patients who developed bacteremia (<jats:italic>n<\/jats:italic> = 11) during the AHSCT course had lower THBS\u20101 concentration compared with those without (<jats:italic>n<\/jats:italic> = 19) (22.88 \u00b1 11.53\u00a0\u00b5g\/mL vs. 15.24 \u00b1 5.62\u00a0\u00b5g\/mL, <jats:italic>p<\/jats:italic> = .0325). The ROC curve analysis revealed that THBS\u20101 serum concentration at the first day of BeEAM\/BEAM regimen had an area under the curve of 0.732 (95%CI: 0.5390.925, <jats:italic>p<\/jats:italic> = .0186) with an optimal cut\u2010off value of 16.5\u00a0\u00b5g\/ml resulting in 82% Sensitivity and 53% Specificity for predicting bacteremia with a median of 11 days before its occurrence. Patients with lower THBS\u20101 concentrations experienced febrile neutropenia significantly earlier, with a median difference of 5 days (<jats:italic>p<\/jats:italic> = .0037). Patients with a low concentration of THBS\u20101 had a higher risk of bacteremia and a shorter time to febrile neutropenia, indicating its potential value as a complications biomarker. Patients with lower serum THBS\u20101 concentrations, indicating an increased risk, may be more suitable for an inpatient AHSCT procedure, where close monitoring and immediate intervention are accessible.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14212-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14212","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T09:28:48Z","timestamp":1702978128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A low thrombospondin\u20101 serum concentration is related to increased bacteremia risk in lymphoma patients treated with BeEAM\/BEAM conditioning regimen and autologous stem cell transplantation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-7985","authenticated-orcid":false,"given":"Kacper","family":"Ko\u015bcielny","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Mikulski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Lodz Poland"},{"name":"Department of Hematooncology Copernicus Memorial Hospital in Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Lodz  Lodz Poland"},{"name":"Department of Hematology and Transplantology Copernicus Memorial Hospital in Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Wyka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oncology and Hematology Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Misiewicz","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Perdas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Wierzbowska","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Lodz  Lodz Poland"},{"name":"Department of Hematology and Transplantology Copernicus Memorial Hospital in Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Fendler","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.20"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNONC.2020.11.014"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5603\/Hem.a2020.0028"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0031"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2706"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.6028"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.02.068"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2019.08.003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBMT.2019.12.772"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEMCDB.2023.05.008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102010\u201001\u2010265561"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A006627"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS22094570"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MATBIO.2014.01.012"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12079\u2010023\u201000722\u20105\/FIGURES\/1"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010152179"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2023.1250355"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAA467"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.111.6.3077"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.109.3.1341"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20100643"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2017.7140\/ASSET\/IMAGES\/LARGE\/FIGURE15.JPEG"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2019.01567\/BIBTEX"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/S40635\u2010017\u20100120\u2010Y"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.06\u20107992COM"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496033"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:36:24Z","timestamp":1721198184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/tid.14212"],"URL":"https:\/\/doi.org\/10.1111\/tid.14212","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"type":"print","value":"1398-2273"},{"type":"electronic","value":"1399-3062"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"2023-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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