{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:37:52Z","timestamp":1789756672309,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenovirus infection (ADVi) is an emergent complication in adult patients undergoing allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) and is associated with poor outcome. Available data on risk factors and optimal management of ADVi in adult allo\u2010HSCT recipients are limited, and recommendations on monitoring and pre\u2010emptive therapy are mainly based on pediatric data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center, retrospective study, we reported all cases of positive ADV\u2010DNA from adult patients undergoing allo\u2010HSCT in the period 2014\u20132019. The study aimed to describe the incidence of ADVi at day +180 post\u2010transplant. Secondly to describe timing, clinical presentation, risk factors, and outcome of ADVi and to analyze the application of a screening strategy in our cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 445 allo\u2010HSCT recipients, the day +180 incidence was: 9% (39\/445) for ADVi, 5% (24\/445) for ADV viremia (ADVv), and 3% (15\/445) for localized ADVi. The median time to ADVi was 65 (IQR 19; 94) days after HSCT. ADVv\u2010related mortality was 13% (3\/24), all cases occurring with blood max\u2010ADV\u2010DNA &gt; 10^3 cp\/mL. Independent risk factors for ADVi were diagnosis of lymphoproliferative disease (<jats:italic>p<\/jats:italic> = .011) and acute graft\u2010versus\u2010host\u2010disease (<jats:italic>p<\/jats:italic> = .021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our cohort, ADVi and ADVv were more frequent than previously reported. ADVv with max\u2010ADV\u2010DNA &gt; 10^3 cp\/mL was associated with ADV\u2010related mortality, thus careful monitoring and early initiation of treatment are advisable.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14215-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14215","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:49:04Z","timestamp":1704775744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adenovirus infection in adult patients undergoing allogeneic hematopoietic stem cell transplant: Incidence, clinical management, and outcome"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9716-5538","authenticated-orcid":false,"given":"Elisa","family":"Balletto","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Division of Infectious Diseases IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ponzano","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Section of Biostatistics University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Raiola","sequence":"additional","affiliation":[{"name":"Division of Trapianto di cellule staminali e terapie cellulari San Martino Hospital  Genoa 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