{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:05:42Z","timestamp":1786716342477,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) infections among hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients impose a significant health care resource utilization (HCRU)\u2010related economic burden. Maribavir (MBV), a novel anti\u2010viral therapy (AVT), approved by the United States Food and Drug Administration for post\u2010transplant CMV infections refractory (with\/without resistance) to conventional AVTs has demonstrated lower hospital length of stay (LOS) versus investigator\u2010assigned therapy (IAT; valgancilovir, ganciclovir, foscarnet, or cidofovir) in a phase 3 trial (SOLSTICE). This study estimated the HCRU costs of MBV versus IAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An economic model was developed to estimate HCRU costs for patients treated with MBV or IAT. Mean per\u2010patient\u2010per\u2010year (PPPY) HCRU costs were calculated using (i) annualized mean hospital LOS in SOLSTICE, and (ii) CMV\u2010related direct costs from published literature. Probabilistic sensitivity analysis with Monte\u2010Carlo simulations assessed model robustness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 352 randomized patients receiving MBV (<jats:italic>n<\/jats:italic> = 235) or IAT (<jats:italic>n<\/jats:italic> = 117) for 8 weeks in SOLSTICE, 40% had HSCT and 60% had SOT. Mean overall PPPY HCRU costs of overall hospital\u2010LOS were $67,205 (95% confidence interval [CI]: $33,767, $231,275) versus $145,501 (95% CI: $62,064, $589,505) for MBV and IAT groups, respectively. Mean PPPY ICU and non\u2010ICU stay costs were: $32,231 (95% CI: $5,248, $184,524) versus $45,307 (95% CI: $3,957, $481,740) for MBV and IAT groups, and $82,237 (95% CI: $40,397, $156,945) MBV versus $228,329 (95% CI: $94,442, $517,476) for MBV and IAT groups, respectively. MBV demonstrated cost savings in over 99.99% of simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis suggests that Mean PPPY HCRU costs were 29%\u201364% lower with MBV versus other\u2010AVTs.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14216-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14216","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T06:08:48Z","timestamp":1705298928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytomegalovirus related hospitalization costs among hematopoietic stem cell and solid organ transplant recipients treated with maribavir versus investigator\u2010assigned therapy: A US\u2010based study"],"prefix":"10.1111","volume":"26","author":[{"given":"Bob G.","family":"Schultz","sequence":"first","affiliation":[{"name":"US Medical Affairs Outcomes Research Takeda Pharmaceuticals U.S.A., Inc. Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bullano","sequence":"additional","affiliation":[{"name":"US Medical Affairs Outcomes Research Takeda Pharmaceuticals U.S.A., Inc. Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-9600","authenticated-orcid":false,"given":"Deepika","family":"Paratane","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Anlitiks, Inc. Windermere Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Anlitiks, Inc. Windermere Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000160"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12686"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2010.11.011"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2015(07)09"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70158-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp090424"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy696"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-128227"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa439.762"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2854-2"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.02.010"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-6367(22)00213-5"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714656"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab988"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S303052"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1051"},{"key":"e_1_2_13_21_1","unstructured":"HCUPnet. 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