{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:53:55Z","timestamp":1775260435508,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberculosis (TB) is a common infection in chronic kidney disease. The prolonged therapy of TB can delay kidney transplantation in patients on antitubercular therapy (ATT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective single\u2010center study to analyze the safety of kidney transplantation and its outcomes in patients undergoing transplantation while on the continuation phase of ATT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2013 and 2022, 30 patients underwent kidney transplantation while on ATT. Median age was 38 years and 70% were males. Majority of the patients (86.7%) had extrapulmonary tuberculosis, most common site of involvement being tubercular lymphadenitis. 14\/30 patients had microbiological\/histopathological diagnosis of TB and the rest were diagnosed\u00a0by ancillary tests. Patients were treated with 4 drug ATT (isoniazid, rifampicin, pyrazinamide, ethambutol) before transplantation for aminimum of 2 months. Post\u2010transplantation fluoroquinolone\u2010based non\u2010rifamycin ATT was used (median duration 11 months). All patients completed therapy. At 2 years, there was 100% patient survival and 96.7% graft survival. Median eGFR at 6, 12, and 24 months post\u2010transplantation was 71.9, 64.7, and 67\u00a0mL\/min\/1.73m<jats:sup>2<\/jats:sup>, respectively. The percentage of patients suffering a biopsy proven acute rejection at 6, 12, and 24 months was 3.3%, 6.7%, and 6.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Kidney transplantation can be done in patients with TB who have a satisfactory response to the intensive phase of the ATT. The decision for transplantation while on the continuation phase of\u00a0ATT should be individualized. In our experience, there is excellent patient and graft survival in these patients with a low risk of failure of ATT or relapse of TB.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14242-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14242","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T09:49:04Z","timestamp":1706176144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kidney transplantation in patients on anti\u2010tubercular therapy: A single centre observational study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-306X","authenticated-orcid":false,"given":"Pallavi","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Nephrology Vardhman Mahavir Medical College and Safdarjung Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Bagai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Medicine Max Superspeciality Hospital, Saket  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Medicine Max Superspeciality Hospital, Saket  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Medicine Max Superspeciality Hospital, Saket  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagandeep","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Medicine Max Superspeciality Hospital, Saket  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-2575","authenticated-orcid":false,"given":"Dinesh","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplant Medicine Max Superspeciality Hospital, Saket  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Tuberculosis.WHO.int. Accessed August 8 2023.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/tuberculosis"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.05.046"},{"key":"e_1_2_10_4_1","first-page":"124","volume-title":"Toman's Tuberculosis: Case Detection, Treatment and Monitoring.","author":"Frieden T","year":"2004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004521"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2320\u20108775.196644"},{"key":"e_1_2_10_7_1","unstructured":"Index TB guidelines.tbcindia.gov.in Accessed August 8 2023.https:\/\/tbcindia.gov.in\/WriteReadData\/l892s\/5585665076Index\u2010TB%20Guidelines.pdf"},{"key":"e_1_2_10_8_1","unstructured":"Tuberculosis profile India. Accessed August 8 2023. Worldhealthorg.shinyapps.io\/https:\/\/worldhealthorg.shinyapps.io\/tb_profiles\/?_inputs_%26entity_type=%22country%22%26lan=%22EN%22%26iso2=%22IN%22"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175\u20108239\u2010JBN\u20102020\u20100189"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.09.040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000116870.10012.5d"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017822"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000183583"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"112","article-title":"Drug interaction between rifampicin and sirolimus in transplant patients","volume":"22","author":"Ngo BT","year":"2011","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.62091"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6369.923"},{"issue":"3","key":"e_1_2_10_19_1","first-page":"404","article-title":"Tuberculosis in Egyptian kidney transplant recipients: study of clinical course and outcome","volume":"16","author":"el\u2010Agroudy AE","year":"2003","journal-title":"J Nephrol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19069"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.12.065"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13893"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13816"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02308\u20102016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00425\u201016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.133173"},{"key":"e_1_2_10_27_1","unstructured":"Treatment of tuberculosis in renal disease in adults. Health.qld.gov.au. Accessed Aug 8 2023.https:\/\/www.health.qld.gov.au\/__data\/assets\/pdf_file\/0024\/444507\/tb\u2010guideline\u2010renal.pdf"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12641"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13513"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13513"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"138","article-title":"Management of tuberculosis in special situations","volume":"22","author":"Bedi RS","year":"2005","journal-title":"Lung India"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:51:57Z","timestamp":1718711517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/tid.14242"],"URL":"https:\/\/doi.org\/10.1111\/tid.14242","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14242"}}