{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:29Z","timestamp":1753879589194,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002382","UL1TR002378"],"award-info":[{"award-number":["TL1TR002382","UL1TR002378"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI144036"],"award-info":[{"award-number":["K23AI144036"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytomegalovirus (CMV) infections are a major source of morbidity and mortality in solid organ transplant recipients. Prophylactic, preemptive, and hybrid prevention strategies have traditionally been the mainstay of CMV prevention but there is growing interest in the use of CMV cell\u2010mediated immune assays to inform novel approaches to risk stratification. Recent evidence suggests that CMV interferon\u2010gamma release assays can offer predictive insights into the risk for CMV\u2010related illnesses, raising the potential for tailored CMV prevention strategies anchored to each individual's unique CMV immune profile. However, the predictive capacity of these assays for CMV\u2010related illnesses can be profoundly influenced by when they are performed relative to transplant, and the induction immunosuppressive regimen the patient has received. In this review, we explore the relevant literature shaping our understanding of the optimal use of these assays. Furthermore, we also highlight the benefits of quantifying the CD4+ and CD8+ T\u2010Cell responses to CMV, which is offered by some interferon\u2010gamma release assays utilizing intracellular cytokine staining, for providing a holistic assessment of the recovery of cell\u2010mediated immunity post\u2010induction immunosuppression.<\/jats:p>","DOI":"10.1111\/tid.14245","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:00:36Z","timestamp":1706688036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing cytomegalovirus prevention in solid organ transplant recipients: The promise of cell\u2010mediated immune assays"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-9520","authenticated-orcid":false,"given":"Vivek B.","family":"Beechar","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun K.","family":"Phadke","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-2444","authenticated-orcid":false,"given":"Stephanie M.","family":"Pouch","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-4599","authenticated-orcid":false,"given":"Michael H.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Emory University School of Medicine  Atlanta Georgia 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