{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:38:43Z","timestamp":1789756723999,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reactivation of viral infections, in particular cytomegalovirus (CMV) and adenovirus (ADV), cause morbidity and non\u2010relapse\u2010mortality in states of immune deficiency, especially after allogeneic hematopoietic cell transplantation (allo\u2010HCT). Against the background of few available pharmacologic antiviral agents, limited by toxicities and resistance, adoptive transfer of virus\u2010specific T\u2010cells (VST) is a promising therapeutic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective analysis of adult patients treated with ADV\u2010 or CMV\u2010specific T\u2010cells in 2012\u20132022. Information was retrieved by review of electronic health records. Primary outcome was a response to VST by decreasing viral load or clinical improvement. Secondary outcomes included overall survival and safety of VST infusion, in particular association with graft\u2010versus\u2010host disease (GVHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten patients were included, of whom four were treated for ADV, five for CMV, and one for ADV\u2010CMV\u2010coinfection. Cells were derived from stem cell donors (6\/10) or third\u2010party donors (4\/10). Response criteria were met by six of 10 patients (4\/4 ADV, 2\/5 CMV, and 0\/1 ADV\u2010CMV). Overall survival was 40%. No infusion related adverse events were documented. Aggravation of GVHD after adoptive immunotherapy was observed in two cases, however in temporal association with a conventional donor lymphocyte infusion and a stem cell boost, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this cohort, CMV\u2010 and ADV\u2010specific T\u2010cell therapy appear to be safe and effective. We describe the first reported case of virus\u2010specific T\u2010cell therapy for CMV reactivation not associated with transplantation but with advanced HIV infection. This encourages further evaluation of adoptive immunotherapy beyond the context of allo\u2010HCT.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14296-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14296","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T21:49:54Z","timestamp":1717451394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adenovirus\u2010 and cytomegalovirus\u2010specific adoptive T\u2010cell therapy in the context of hematologic cell transplant or HIV infection \u2013 A single\u2010center experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0628-870X","authenticated-orcid":false,"given":"Benedikt","family":"Obermaier","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-8537","authenticated-orcid":false,"given":"Luca","family":"Hensen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Faul","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-2618","authenticated-orcid":false,"given":"Wolfgang","family":"Bethge","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5442-2805","authenticated-orcid":false,"given":"Claudia","family":"Lengerke","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichard","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Clinical Immunology, and Rheumatology Center for Internal Medicine 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