{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:58:15Z","timestamp":1791388695508,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effect of belatacept on BK polyomavirus (BKPyV) control remains largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a propensity matched retrospective cohort study in adult kidney transplant recipients (KTR) transplanted between 2016\u20132020 who received a belatacept\u2010 versus tacrolimus\u2010based immunosuppression regimen. A continuous time multi\u2010state Markov model was used to evaluate BKPyV replication dynamics (BKPyV\u2010dyn). Three BKPyV\u2010dyn states were defined: BKPyV\u2010dyn1 (viral load &lt;3 log\n                      <jats:sub>10<\/jats:sub>\n                      ), BKPyV\u2010dyn2 (viral load \u2265 3 log\n                      <jats:sub>10<\/jats:sub>\n                      and \u22644 log\n                      <jats:sub>10<\/jats:sub>\n                      ), and BKPyV\u2010dyn3 (viral load &gt;4 log\n                      <jats:sub>10<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred eighty KTR on belatacept\u2010 and 280 KTR on tacrolimus\u2010based regimens were compared. The probability of transitioning between BKPyV\u2010dyn states and time spent in each state in both groups was comparable. Total duration in BKPyV\u2010dyn\u20101 was 632.1 days (95% CI 612.1, 648.5) for belatacept versus 615.2 days (95% CI 592.5, 635.8) for tacrolimus, BKPyV\u2010dyn\u20102 was 49.2 days (95% CI 41.3, 58.4) for belatacept versus 55.6 days (95% CI 46.5, 66.8) for tacrolimus, and BKPyV\u2010dyn\u20103 was 48.7 days (95% CI 37.1, 363.1) for belatacept versus 59.2 days (95% CI 45.8, 73.5) for tacrolimus. BKPyV associated nephropathy (PyVAN) occurred in 3.9% in belatacept\u2010 and 3.9% tacrolimus\u2010treated KRT (\n                      <jats:italic>P<\/jats:italic>\n                      &gt;\u00a0.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Compared with tacrolimus\u2010based immunosuppression, belatacept based immunosuppression was not associated with increased risk of BKPyV\u2010DNAemia or nephropathy.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14298-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14298","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:44:20Z","timestamp":1719801860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Belatacept\u2010based immunosuppression does not confer increased risk of BK polyomavirus\u2010DNAemia relative to tacrolimus\u2010based immunosuppression"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-0638","authenticated-orcid":false,"given":"Emily M.","family":"Eichenberger","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-6464","authenticated-orcid":false,"given":"Wairimu","family":"Magua","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Rickert","sequence":"additional","affiliation":[{"name":"R Consortium  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Karadkhele","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kazem","family":"Fallahzadeh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payaswini","family":"Vasanth","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Surgery Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2022.10.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081616"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08420813"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.12.016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13528"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02402.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000156165.83160.09"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2005.00742.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/THC-2005-13204"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14353"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2009.03005.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010020\u201000296\u20104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13983"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010019\u20103781\u20101"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7189"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12976\u2010021\u201000145\u2010y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.09.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002366"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v038.i08"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/23737484.2017.1361366"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1191\/0962280202sm279ra"},{"key":"e_1_2_10_25_1","unstructured":"R Core Team.R: a language and environment for statistical computing. 2022.https:\/\/www.R\u2010project.org\/"},{"key":"e_1_2_10_26_1","unstructured":"RStudio: Integrated Development for R.http:\/\/www.rstudio.com\/"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_10_28_1","unstructured":"R.A package for survival analysis in R. 2023.https:\/\/CRAN.R\u2010project.org\/package=survival"},{"key":"e_1_2_10_29_1","unstructured":"survminer: Drawing Survival Curves using \u201cggplot2\u201d. 2021.https:\/\/CRAN.R\u2010project.org\/package=survminer"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780130803"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101857"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001589"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.14298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:29:14Z","timestamp":1773646154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/tid.14298"],"URL":"https:\/\/doi.org\/10.1111\/tid.14298","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14298"}}