{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:40:51Z","timestamp":1790995251893,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Previous studies showed HIV\u2010negative immunocompromised patients are susceptible to\n Pneumocystis<\/jats:italic>\n pneumonia (PCP). However, the PCP outcome has not been compared among HIV\u2010negative immunocompromised patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this retrospective cohort study at the University Health Network, we included all HIV\u2010negative immunocompromised patients who fulfilled the European Organization for Research and Treatment of Cancer (EORTC) PCP diagnosis criteria from December 2018 to December 2019. We compared the demographics, comorbidities, course of illness, and PCP outcome (28\u2010day mortality and composite outcome [i.e., death or intensive care unit (ICU) admission]) between solid organ transplant (SOT) and non\u2010SOT patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 160 non\u2010HIV patients with PCP diagnoses, 118 patients fulfilled EORTC criteria (76 males [64.4%], median [range] age: 65.5 [21\u201387] years). PCP presentation in SOT recipients (\n n<\/jats:italic>\n \u00a0=\u00a014) was more severe than non\u2010SOT patients (\n n<\/jats:italic>\n \u00a0=\u00a0104): acute presentation (onset <7 days before admission: 11\/14 [78.6%] vs. 51\/104 [56%],\n p<\/jats:italic>\n \u00a0=\u00a0.037), shortness of breath (100% vs. 75\/104 [74.3%],\n p<\/jats:italic>\n \u00a0=\u00a0.037), median [range] O\n 2<\/jats:sub>\n saturation (88% [75%, 99%] vs. 92%[70%, 99%],\n p<\/jats:italic>\n \u00a0=\u00a0.040), and supplemental O\n 2<\/jats:sub>\n requirement (12\/14 [85.7%] vs. 59\/104 [56.7%],\n p<\/jats:italic>\n \u00a0=\u00a0.044). The mortality [4\/14, (28.6%) vs. 15\/104 (14.4%),\n p<\/jats:italic>\n \u00a0=\u00a0.176], ICU admission (10\/14 [71.4%] vs. 18\/104 [17.3%],\n p<\/jats:italic>\n \u00a0<\u00a0.0001), and mechanical ventilation (8\/14 [57.1%] vs. 18\/104 [17.3%],\n p<\/jats:italic>\n \u00a0=\u00a0.0007) in SOT patients was different from non\u2010SOT patients. In multivariable analysis, SOT recipients were at greater risk of composite outcome than non\u2010SOT patients (aOR [CI95%]: 12.25 [3.08\u201348.62],\n p<\/jats:italic>\n \u00a0<\u00a0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n PCP presentation and outcomes in SOT recipients are more severe than in non\u2010SOT patients. Further studies are required to explore the biological reasons for this difference.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.14321","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T04:04:49Z","timestamp":1719461089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcome of\n Pneumocystis<\/i>\n pneumonia in transplant and non\u2010transplant HIV\u2010negative immunocompromised patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Hanan","family":"Albasata","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Rashid Hospital Dubai Academic Health Corporation Dubai United Arab Emirates"},{"name":"Transplant Infectious Diseases Program, Ajmera Transplant Centre, Division of Infectious Diseases, Department of Medicine University of Toronto University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gioia","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Program, Ajmera Transplant Centre, Division of Infectious Diseases, Department of Medicine University of Toronto University Health Network Toronto Ontario Canada"},{"name":"Infectious Diseases Department Hospital Ram\u00f3n y Cajal IRYCIS (Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria) Universidad de Alcal\u00e1 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Program, Ajmera Transplant Centre, Division of Infectious Diseases, Department of Medicine University of Toronto University Health Network Toronto Ontario Canada"},{"name":"Biostatistics Research Unit University Health Network Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Poutanen","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Program, Ajmera Transplant Centre, Division of Infectious Diseases, Department of Medicine University of Toronto University Health Network Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine & Pathobiology University Health Network\/Sinai Health Department of Microbiology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-2458","authenticated-orcid":false,"given":"Seyed M.","family":"Hosseini\u2010Moghaddam","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Program, Ajmera Transplant Centre, Division of Infectious Diseases, Department of Medicine University of Toronto University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833a3967"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32834cac17"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030\u2010199903110\u201000020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103062.2012.00739.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010016\u20101855\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.12.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2009.131668"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy682"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof1030293"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1805"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20103399559"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/323129"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/MMY\/MYV023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/THX.2009.117846"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/319866"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJT.2023.11.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02878\u201019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006807"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13587"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/OFID\/OFAD639"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.729193"}],"container-title":["Transplant 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