{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:23Z","timestamp":1787016143376,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR001870"],"award-info":[{"award-number":["KL2TR001870"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011074","name":"Liver Center, University of California, San Francisco","doi-asserted-by":"publisher","award":["P30DK026743"],"award-info":[{"award-number":["P30DK026743"]}],"id":[{"id":"10.13039\/100011074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM104942"],"award-info":[{"award-number":["U54GM104942"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115458"],"award-info":[{"award-number":["U54GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n While coronavirus disease 2019 (COVID\u201019) is no longer a public health emergency, certain patients remain at risk of severe outcomes. To better understand changing risk profiles, we studied the risk factors for patients with and without solid organ transplantation (SOT) through the various waves of the pandemic.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using the National COVID Cohort Collaborative we studied a cohort of adult patients testing positive for COVID\u201019 between January 1, 2020, and May 2, 2022. We separated the data into waves of COVID\u201019 as defined by the Centers for Disease Control. In our primary outcome, we used multivariable survival analysis to look at various risk factors for hospitalization in those with and without SOT.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 3,570,032 patients were captured. We found an overall risk attenuation of adverse COVID\u201019\u2010associated outcomes over time. In both non\u2010SOT and SOT populations, diabetes, chronic kidney disease, and congestive heart failure were risk factors for hospitalization. For SOT specifically, longer time periods between transplant and COVID\u201019 were protective and age was a risk factor. Notably, asthma was not a risk factor for major adverse renal cardiovascular events, hospitalization, or mortality in either group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our study provides a longitudinal view of the risks associated with adverse COVID\u2010related outcomes amongst SOT and non\u2010SOT patients, and how these risk factors evolved over time. Our work will help inform providers and policymakers to better target high\u2010risk patients.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.14333","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:29:44Z","timestamp":1720535384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for severe outcomes of coronavirus disease 2019 through the waves of the pandemic: Comparing patients with and without solid organ transplantation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-293X","authenticated-orcid":false,"given":"Stephen B.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Saskatchewan Regina Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"French","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Wright Center for Clinical and Translational Research Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrod A.","family":"Anzalone","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Olex","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Wright Center for Clinical and Translational Research Richmond Virginia 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