{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:07:45Z","timestamp":1773648465778,"version":"3.50.1"},"reference-count":81,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1U01AI181927\u00a0CoFAR"],"award-info":[{"award-number":["1U01AI181927\u00a0CoFAR"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Among patients with hematopoietic stem cell transplants, infections, particularly multidrug\u2010resistant infections, pose a grave threat. In this setting, penicillin allergy labels are both common and harmful. Though the majority of patients who report penicillin allergy can actually tolerate penicillin, penicillin allergy labels are associated with use of alternative antibiotics, which are often more broad spectrum, less effective, and more toxic. In turn, they are associated with more severe infections, multidrug\u2010resistant infections,\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      , and increased mortality. Evaluating penicillin allergy labels can immediately expand access to preferred therapeutic options, which are critical to care in patients with recent hematopoietic stem cell transplants. Point\u2010of\u2010care assessment and clinical decision tools now exist to aid the nonallergist in assessment of penicillin allergy. This can aid in expanding use of other beta\u2010lactam antibiotics and assist in risk\u2010stratifying patients to determine a testing strategy. In patients with low\u2010risk reaction histories, direct oral challenges can be employed to efficiently delabel patients across clinical care settings. We advocate for multidisciplinary efforts to evaluate patients with penicillin allergy labels prior to transplantation.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14350-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14350","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T08:28:39Z","timestamp":1722846519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-2705","authenticated-orcid":false,"given":"Ami P.","family":"Belmont","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Cosby A.","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn C.","family":"Guyer","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Jennifer","family":"Edelman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Social and Behavioral Sciences Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-125232"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx050"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.06.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.028"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2400"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-04991-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.08.027"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.08.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2014.01.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030592"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.149"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13168"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12390"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.025"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1575"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202001\u20100089LE"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.03.049"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1762"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.2227"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.026"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9763"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.232"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815617129"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-364265"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.012"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1025"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy037"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.06.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2022.09.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.05.027"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.12.017"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13440"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.12.001"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081\u20101206(10)60621\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.028"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.07.024"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218782372"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S206027"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756\u2010015\u20100063\u20106"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.041"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.04.009"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.9820"},{"key":"e_1_2_9_51_1","first-page":"ofw155","volume-title":"Implementation of an Infectious Disease Fellow\u2010Managed Penicillin Allergy Skin Testing Service","author":"Heil EL","year":"2016"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.08.043"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.025"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.038"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.020"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlz072"},{"key":"e_1_2_9_57_1","first-page":"ofy306","volume-title":"The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study","author":"Trubiano JA","year":"2018"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.08.020"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.1572"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0403"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.05.037"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.2986"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.1572"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.037"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2296068"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.006"},{"issue":"11","key":"e_1_2_9_68_1","first-page":"3209","article-title":"Antibiotic allergy testing improves antibiotic appropriateness in patients with cancer","volume":"73","author":"Trubiano JA","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix244"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13175"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00651.x"},{"key":"e_1_2_9_72_1","unstructured":"StoneC.The effect of providing stratification of low risk penicillin allergies on penicillin allergy label removal. Clinical Trials.gov identifier: NCT03702270. Accessed May 29 2024.https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03702270"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000950"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2311"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012\u2010016\u20100398\u20102"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13885"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.03.013"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.05.032"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.07.056"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.07.003"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.027"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.16776"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.14350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:29:19Z","timestamp":1773646159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/tid.14350"],"URL":"https:\/\/doi.org\/10.1111\/tid.14350","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]},"assertion":[{"value":"2024-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14350"}}