{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:47:35Z","timestamp":1773218855347,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A biovigilance program that has oversight of the entire organ and tissue donation and transplantation pathways underpins the quality and safety system in the United Kingdom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A synopsis of the microbiological characterization of potential deceased organ donors and the processes for notification and investigation of possible donor\u2010derived infections are described. A summary of the outcome of investigations performed over a 10\u2010year period and a subset data frame of 5 years showing the proportion of infection incidents in relation to other incident types are also presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single, centralized system overseeing the entire donation and transplantation pathway has become an essential part of transplantation practice across the United Kingdom. Revision of processes and management options, awareness of clinical conditions, and review of guidance are some examples of benefits gained over time. Transmission figures provided reflect the UK setting; these should be interpreted in context, as donor and recipient epidemiology differs across regions and nations. Despite a well\u2010established system in place, under reporting of cases continues to occur, with ongoing efforts to reassure professionals and patients of the true benefits of biovigilance in driving improvements in practice and patient outcomes.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14351-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14351","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T19:05:11Z","timestamp":1722107111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perspectives on biovigilance and transmission of infection of donor origin in deceased organ donation\u2014The evolving scenario in the United Kingdom"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-8091","authenticated-orcid":false,"given":"Ines","family":"Ushiro\u2010Lumb","sequence":"first","affiliation":[{"name":"Department of Organ and Tissue donation and Transplantation, Pathology NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie","family":"Geoghegan","sequence":"additional","affiliation":[{"name":"Department of Organ and Tissue donation and Transplantation, Pathology NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olive","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Pathology NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Organ and Tissue donation and Transplantation NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Vigilance andSurveillance Expert Advisory Committee (VSEAC).The Australian Vigilance and Surveillance System for Organ Donation and Transplantation 2022 Report. Accessed April 29 2024.https:\/\/www.donatelife.gov.au\/sites\/default\/files\/2023\u201006\/OTA_2022_VSEAC_Annual_Report.pdf"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16178"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11610"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/frtra.2024.1307946"},{"key":"e_1_2_8_6_1","unstructured":"Human Tissue Authority.The Quality and Safety of Organs Intended for Transplantation: A documentary framework.2024. Accessed June 24 2024.https:\/\/www.hta.gov.uk\/guidance\u2010professionals\/guidance\u2010sector\/organ\u2010donation\u2010and\u2010transplantation\/quality\u2010and\u2010safety\u2010organs"},{"key":"e_1_2_8_7_1","unstructured":"Advisory Committee on the Safety of Blood Tissue and Organs.Microbiology Safety Guidelines.2018 revised 2023. Accessed 29 April 2024.https:\/\/assets.publishing.service.gov.uk\/media\/65a95baaed27ca000d27b273\/SaBTO\u2010microbiological\u2010safety\u2010guidelines.pdf"},{"key":"e_1_2_8_8_1","unstructured":"Advisory Virology Subcommittee.Organ donation and seasonal influenza: guidance from SaBTO's virology review subcommittee. 2019. Accessed 2024.https:\/\/www.gov.uk\/government\/publications\/organ\u2010donation\u2010and\u2010seasonal\u2010flu\/organ\u2010donation\u2010and\u2010seasonal\u2010influenza\u2010guidance\u2010from\u2010sabtos\u2010virology\u2010review\u2010subcommittee"},{"key":"e_1_2_8_9_1","unstructured":"Advisory Committee on the Safety of Blood Tissues and Organs.Protecting patients from hepatitis E: SaBTO guidelines.2017. Accessed April 29 2024.https:\/\/assets.publishing.service.gov.uk\/media\/5a7c41ea40f0b62dffde0e0f\/Hepatitis_E_Guidelines.pdf"},{"key":"e_1_2_8_10_1","unstructured":"Advisory Virology Subcommittee.SaBTO Virology Review Subcommittee Recommendations on KSHV: Executive Summary.2023. Accessed April 29 2024.https:\/\/www.gov.uk\/government\/publications\/sabto\u2010virology\u2010subcommittee\u2010recommendations\u2010on\u2010kshv\u2010infection\/sabto\u2010virology\u2010subcommittee\u2010recommendtaions\u2010on\u2010kshv\u2010executive\u2010summary"},{"key":"e_1_2_8_11_1","unstructured":"Royal College of Pathologists.Standards for microbiology investigations (SMI).2020. Accessed April 29 2024.https:\/\/www.rcpath.org\/static\/26683e7e\u20105354\u201042bd\u201081fca649d8b4d60d\/3b3fff58\u2010c400\u20104a63\u20109338bca570cd247b\/UK\u2010SMI\u2010B\u201062i1\u2010Abdominal\u2010organ\u2010transport\u2010fluid\u2010testing\u2010January\u20102020.pdf"},{"key":"e_1_2_8_12_1","first-page":"443","volume-title":"Guide to the Quality and Safety of Organs for Transplantation","author":"Ushiro\u2010Lumb I","year":"2022"},{"key":"e_1_2_8_13_1","unstructured":"Organ and Tissue Donation and Transplantation NHSBT UK.Governance and Quality in Transplantation.2024. Accessed June 24 2024.https:\/\/www.odt.nhs.uk\/odt\u2010structures\u2010and\u2010standards\/governance\u2010and\u2010quality"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11673"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102020\u2010101659"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T16:48:18Z","timestamp":1732121298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":14,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/tid.14351"],"URL":"https:\/\/doi.org\/10.1111\/tid.14351","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]},"assertion":[{"value":"2024-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14351"}}