{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:25:55Z","timestamp":1789053955256,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid organ transplantation (SOT) has expanded significantly in Asia over past few decades. Donor\u2010derived infections (DDIs) remain a significant concern as they may adversely impact transplant outcomes. We aim to review the existing regulatory frameworks, screening protocols, and management practices for DDIs in Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reached out to transplant infectious diseases experts in Asia to provide standardized data on annual SOT numbers, incidence of DDIs, regulatory frameworks, donor and recipient screening protocols, and DDI surveillance measures. We present the data from Singapore, Japan, and Thailand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Donor screening for HIV, hepatitis B, hepatitis C, and syphilis is mandatory in all countries. Additionally, Japan screens for HTLV\u20101 antibody due to its endemicity. We also reviewed the protocols for screening and prevention of endemic infections in Asia. Singapore is the only country implementing universal screening for all donors for dengue, Zika, and chikungunya via blood and urine RT\u2010PCR. Strongyloidiasis screening is not routinely done, although some transplant centers empirically give ivermectin prophylaxis to organ recipients. Tuberculosis screening with a donor questionnaire and chest radiograph is common for deceased donors, and some centers do Interferon Gamma Release Assay test for living donors. We also found a significant gap in the surveillance and reporting of potential DDIs in Asia and the overall incidence of DDIs in Asia is unknown and likely underreported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The experiences of Singapore, Japan, and Thailand offer valuable insights into current practices and the unmet needs regarding a DDI registry and call for coordinated efforts to address this critical issue in the region.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14370-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14370","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T16:14:53Z","timestamp":1725380093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Donor\u2010derived infections\u2014Insights from Singapore, Japan, and Thailand"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-3216","authenticated-orcid":false,"given":"Sophie Seine Xuan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Singapore General Hospital  Singapore Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakpoom","family":"Phoompoung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease and Tropical Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methee","family":"Chayakulkeeree","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease and Tropical Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu Xian","family":"Koh","sequence":"additional","affiliation":[{"name":"National Organ Transplant Unit Ministry of Health  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Kiat","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"National Organ Transplant Unit Ministry of Health  Singapore Singapore"},{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Nyuk Min","family":"Kong","sequence":"additional","affiliation":[{"name":"National Organ Transplant Unit Ministry of Health  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuan Tong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Singapore General Hospital  Singapore Singapore"},{"name":"Duke\u2010NUS Medical School  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