{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:31:59Z","timestamp":1791916319727,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Often, organ transplantation is the only option to improve the life expectancy and quality of life of patients with terminal organ failure. Despite improved donor and organ assessment, a residual risk remains for transmitting infection, tumor, or other disease from the donor to recipients. Analysis, reporting, and managing of donor\u2010derived diseases through a vigilance and surveillance system (V&amp;S) is mandatory in many countries. We report on suspected and proven\/probable donor\u2010derived infections (DDI) in Germany over a period of 8 years (2016\u20132023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All incoming serious\u2010adverse\u2010event and serious\u2010adverse\u2010reaction (SAE\/SAR) reports from 01.01.2016 to 31.12.2023 were evaluated for suspected DDI. Analysis of imputability followed the definition of the US Disease Transmission Advisory Committee (DTAC). Only probable and proven cases according to DTAC classification were defined as DDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 9771 donors in Germany donated post\u2010mortem organs to 27\u00a0919 recipients. In that period 612 SAE\/SAR cases were reported, 377 (62%) involved infections. 41 cases were proven\/probable DDI affecting 58 recipients (seven recipients died, 12%). Suspected infections were bacterial (182\/377, 48%), fungal (135\/377, 36%), viral (55\/377, 15%), and parasitic (5\/377, 1%). In case of bacterial DDI, no recipient died, but organ loss occurred in six recipients. In case of fungal or viral DDI, 19% (3\/16) and 21% (3\/14) of the recipients died, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DDI are rare in solid organ transplantation (58\/27\u00a0919, 0.21%), but when they occur, they are associated with high morbidity and mortality in affected recipients. Careful and detailed donor evaluation and a reliable V&amp;S help improve recipient safety.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14372-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14372","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T14:10:28Z","timestamp":1727100628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perspectives on donor\u2010derived infections from Germany"],"prefix":"10.1111","volume":"26","author":[{"given":"Ana Paula","family":"Barreiros","sequence":"first","affiliation":[{"name":"Gesch\u00e4ftsf\u00fchrende \u00c4rztin, Deutsche Stiftung Organtransplantation, Region Mitte, Organisationszentrale  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00f6hler","sequence":"additional","affiliation":[{"name":"Deutsche Stiftung Organtransplantation, Hauptverwaltung  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"M\u00f6nch","sequence":"additional","affiliation":[{"name":"Verbundprojekt KITTU, Klinik und Poliklinik f\u00fcr Urologie und Kinderurologie, Universit\u00e4tsmedizin Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-7668","authenticated-orcid":false,"given":"Carl\u2010Ludwig","family":"Fischer\u2010Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Deutsche Stiftung Organtransplantation, Region Baden\u2010W\u00fcrttemberg, Organisationszentrale  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rahmel","sequence":"additional","affiliation":[{"name":"Deutsche Stiftung Organtransplantation, Hauptverwaltung  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001635"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13086"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000735"},{"key":"e_1_2_10_5_1","unstructured":"Directive 2010\/53\/EU of the European Parliament and of the Council of 7 July 2010 on standards of quality and safety of human organs intended for transplantation. Accessed May 3 2024.https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/?uri=CELEX:02010L0053\u201020100806"},{"key":"e_1_2_10_6_1","unstructured":"Directive 2012\/25\/EU of 9 October 2012 laying down information procedures for the exchange between Member States of human organs intended for transplantation. 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