{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:10:39Z","timestamp":1767924639227,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preventive management of tuberculosis in liver transplantation (LT) is challenging due to difficulties in detecting and treating latent tuberculosis infection (LTBI). The aim of this study was to analyze the safety and efficacy of a screening strategy for LTBI with the inclusion of moxifloxacin as treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective single\u2010center study of all LTs performed between 2016 and 2019 with a minimum 4\u2010year follow\u2010up and a standardized protocol for the evaluation of LTBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pretransplant LTBI screening was performed in 191\/218 (87.6%) patients, and LTBI was diagnosed in 27.2% of them. Treatment for LTBI was administered to 71.2% of the patients and included moxifloxacin in 75.6% of the cases. After a median follow\u2010up of 1628 days, no cases of active tuberculosis occurred among moxifloxacin\u2010treated patients. The incidence of <jats:italic>Clostridioides difficile<\/jats:italic> (0.46\u00a0vs. 0.38 episodes\/1000 transplant\u2010days; <jats:italic>p<\/jats:italic> = \u00a0.8) and multidrug\u2010resistant gram\u2010negative bacilli infection (0\u00a0vs. 0.7 episodes per 1000 transplant\u2010days; <jats:italic>p<\/jats:italic> = \u00a0.08) were not significantly higher in comparison to patients who did not receive moxifloxacin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A preventive strategy based on systematic LTBI screening and moxifloxacin treatment before LT in positive cases appears safe and effective in preventing the development of tuberculosis in LT recipients. However, our findings are limited by a small sample size; thus, larger studies are required to validate our observations.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14382-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14382","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T12:34:17Z","timestamp":1727526857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of a preventive strategy against tuberculosis in liver transplantation recipients including the treatment of latent infection with moxifloxacin"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-6036","authenticated-orcid":false,"given":"Marina","family":"Fayos","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-3466","authenticated-orcid":false,"given":"Jose Tiago","family":"Silva","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"},{"name":"Antimicrobial Stewardship Team in Hospitalized Patients (PROA\u2010HU12O) University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"},{"name":"School of Medicine Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"},{"name":"School of Medicine Universidad Complutense  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-6057","authenticated-orcid":false,"given":"Tamara","family":"Ruiz\u2010Merlo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases University Hospital \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5097-8750","authenticated-orcid":false,"given":"Alessandro","family":"Visentin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Diagnostics and Public Health University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-0568","authenticated-orcid":false,"given":"Carmelo","family":"Loinaz","sequence":"additional","affiliation":[{"name":"Unit of Hepato\u2010Pancreato\u2010Biliary Surgery and Abdominal Organ Transplantation University Hospital \u201c12 de Octubre\u201d  Madrid 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