{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:46Z","timestamp":1753879606129,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Outcomes after bebtelovimab treatment for COVID\u201019 were favorable for most but not all solid organ transplant recipients (SOTRs) during the era of Omicron BA.2 to BA.5, but effects of timing of bebtelovimab administration on these outcomes are unknown. We sought to compare outcomes of SOTR who received early bebtelovimab (\u201cEBT\u201d, given \u2264\u00a02\u00a0days from diagnosis) versus late bebtelovimab (\u201cLBT\u201d, given between Days 3 and 7), versus no bebtelovimab (NBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of SOTRs with mild\u2010to\u2010moderate COVID\u201019, with endpoint of 30\u2010day COVID\u201019\u2010related hospitalization. Multivariable logistic regression was performed to determine variables associated with receiving EBT, and to assess impact of EBT on hospitalization. A propensity score (PS) was calculated for EBT versus NBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 297 SOTRs, 162 (58.1%) received EBT, 46 (16.5%) LBT, and 71 (25.4%) NBT. Early bebtelovimab treatment was associated with a lower risk of 30\u2010day COVID\u201019\u2010related hospitalization compared to NBT (OR, 0.112 [95% CI, 0.018\u20130.686]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018). There was no significant difference in hospitalization risk between LBT and NBT, suggesting that delayed administration may not confer additional benefits over no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early bebtelovimab treatment in outpatient SOTRs was associated with a lower risk of hospitalization compared to no treatment, while late administration did not show a significant advantage over no treatment. Although bebtelovimab is no longer authorized, these findings suggest that the timing of COVID therapies for SOTRs may be important to optimize outcomes.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14405-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14405","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T19:04:00Z","timestamp":1731783840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Bebtelovimab Treatment Timing on COVID\u201019 Outcomes in Ambulatory Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-4810","authenticated-orcid":false,"given":"Sonsoles","family":"Salto\u2010Alejandre","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Johns Hopkins University  Baltimore USA"},{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willa","family":"Cochran","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-5958","authenticated-orcid":false,"given":"Zishan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-7063","authenticated-orcid":false,"given":"Julie","family":"Langlee","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Boyer","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Freed","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Purekal","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-0029","authenticated-orcid":false,"given":"Ishaan","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7299-7730","authenticated-orcid":false,"given":"Mary Grace","family":"Bowring","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-7455","authenticated-orcid":false,"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-5895","authenticated-orcid":false,"given":"William","family":"Werbel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Johns Hopkins University  Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-3619","authenticated-orcid":false,"given":"Robin K.","family":"Avery","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Johns Hopkins University  Baltimore 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