{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:38:17Z","timestamp":1776843497132,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016767","name":"United Network for Organ Sharing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prior to the 2013 HIV Organ Policy Equity (HOPE) Act, which enabled research on the transplantation of solid organs from donors with human immunodeficiency virus (HIV) to candidates living with HIV, it was prohibited for HIV+ individuals to donate organs in the United States. In 2015, alongside the release of HOPE Act research criteria, the Organ Procurement and Transplantation Network (OPTN) made organ allocation policy and system changes to allow HIV+ to HIV+ transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The OPTN database was queried for all adult kidney registrations ever waiting from November 23, 2015, to December 31, 2022; the cohort was split into a HOPE cohort (ever willing to accept an HIV+ kidney) and a non\u2010HOPE cohort (all remaining). Estimated median waiting times (eMWTs) were calculated using a period prevalent Kaplan\u2010Meier approach; HOPE registrations were matched 1:5 without replacement to non\u2010HOPE registrations using a logistic regression propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using all waiting time, the eMWT for the HOPE cohort was significantly lower than the matched non\u2010HOPE cohort (3.04 years [95% confidence interval {CI}: 2.70, 3.41] versus 5.88 years [95% CI: 5.65, 6.18]). This trend persisted when estimating MWT using other active time and geographical definitions (ignoring geography and donor service area).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that transplantation through the OPTN HOPE variance yields decreases eMWT, perhaps reducing the medium and longer\u2010term impacts of living with HIV.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14411-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14411","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T02:53:26Z","timestamp":1732762406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Estimated Median Waiting Time for Organ Procurement and Transplantation Network Human Immunodeficiency Virus Organ Policy Equity Act Variance Kidney Candidates: A Propensity Score Matched Analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-1091","authenticated-orcid":false,"given":"Amber R.","family":"Fritz","sequence":"first","affiliation":[{"name":"Research Department United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6700-437X","authenticated-orcid":false,"given":"Jesse","family":"Howell","sequence":"additional","affiliation":[{"name":"Research Department United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-5030","authenticated-orcid":false,"given":"Cameron R.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-8498","authenticated-orcid":false,"given":"Samantha M.","family":"Noreen","sequence":"additional","affiliation":[{"name":"Research Department United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-0664","authenticated-orcid":false,"given":"David K.","family":"Klassen","sequence":"additional","affiliation":[{"name":"Office of the Chief Medical Officer United Network for Organ Sharing  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Code of Federal Regulations.OPTN Final Rule. Accessed: March 20 2024 Available from:https:\/\/www.ecfr.gov\/current\/title\u201042\/chapter\u2010I\/subchapter\u2010K\/part\u2010121."},{"key":"e_1_2_9_3_1","unstructured":"Federal Register.Final Human Immunodeficiency Virus (HIV) Organ Policy Equity (HOPE) Act Safeguards and Research Criteria for Transplantation of Organs Infected With HIV. Accessed: March 20 2024 Available from:https:\/\/www.federalregister.gov\/documents\/2015\/11\/25\/2015\u201030172\/final\u2010human\u2010immunodeficiency\u2010virus\u2010hiv\u2010organ\u2010policy\u2010equity\u2010hope\u2010act\u2010safeguards\u2010and\u2010research\u2010criteria."},{"key":"e_1_2_9_4_1","unstructured":"Organ Procurement & Transplantation Network.OPTN Policy. Accessed: March 20 2024 Available from:https:\/\/optn.transplant.hrsa.gov\/media\/eavh5bf3\/optn_policies.pdf."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03506.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-015-0471-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13171"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15494"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002405"},{"key":"e_1_2_9_10_1","article-title":"Temporal Trends of OPTN Hope Act Variance Participation","volume":"22","author":"Wilk A.","year":"2022","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14993"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16205"},{"key":"e_1_2_9_13_1","unstructured":"Federal Register.Organ Procurement and Transplantation: Implementation of the HIV Organ Policy Equity (HOPE) Act. Accessed: September 19 2024 https:\/\/www.federalregister.gov\/documents\/2024\/09\/12\/2024\u201020643\/organ\u2010procurement\u2010and\u2010transplantation\u2010implementation\u2010of\u2010the\u2010hiv\u2010organ\u2010policy\u2010equity\u2010hope\u2010act."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2022.12.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00321-8"},{"key":"e_1_2_9_18_1","volume-title":"R: A Language and Environment for Statistical Computing [computer program]","year":"2016"},{"issue":"3","key":"e_1_2_9_19_1","first-page":"759","article-title":"Wait Time Advantage for Transplant Candidates with HIV Who Accept Kidneys from Donors with HIV under the HOPE Act","volume":"108","author":"Motter J. D.","year":"2024","journal-title":"Transplantation"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab743"},{"issue":"6","key":"e_1_2_9_21_1","article-title":"Why Is the OPTN HOPE Kidney Waiting List Shrinking Despite Short(er) Wait Times?","volume":"23","author":"Fritz A.","year":"2023","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16886"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16411"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13767"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:26:55Z","timestamp":1739550415000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/tid.14411"],"URL":"https:\/\/doi.org\/10.1111\/tid.14411","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14411"}}