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We highlight the multiple challenges that free\u2010living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include <jats:italic>Acanthamoeba<\/jats:italic> infections in their differential diagnosis of a patient with skin, sinus, lung, and\/or brain involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.14425","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T16:23:58Z","timestamp":1735403038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Acanthamoeba<\/i> Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification"],"prefix":"10.1111","volume":"27","author":[{"given":"Camellia T.","family":"Banerjee","sequence":"first","affiliation":[{"name":"Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH)  Bethesda Maryland 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