{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:07:49Z","timestamp":1784167669466,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with cancer are at elevated risk for tuberculosis (TB) reactivation. Diagnosis of latent TB infection and TB disease remains challenging in this patient population despite the advent of interferon\u2010\u03b3 release assays (IGRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed medical records of all patients with cancer who had IGRA testing (QuantiFERON\u2013TB [QFT\u2010TB] or T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      ) at a major cancer center in the United States from June 2010 to July 2017. The results were analyzed with respect to the likelihood of latent TB infection and TB disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1299 patients were included with 1599 tests performed: 586 QFT\u2010TB and 1013 T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      . Forty\u2010nine (4%) patients were diagnosed with latent TB, and four (1%) with TB disease. T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      was more likely to yield an actionable result (positive or negative) than QFT\u2010TB (89%\u00a0vs. 65%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The rate of indeterminate results for QFT\u2010TB was higher than the rate of invalid results for T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      (35% and 10%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). On multivariate analysis, independent predictors of an invalid T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      included prior receipt of alemtuzumab, lower hemoglobin, absolute lymphocyte count, or serum albumin (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 each), whereas the independent predictors of an indeterminate QFT\u2010TB were female gender, prior receipt of systemic corticosteroids, and lower hemoglobin, or serum albumin or higher absolute neutrophil count (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 each).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      yielded more actionable results than QFT\u2010TB in patients with cancer. T\u2010SPOT.\n                      <jats:italic>TB<\/jats:italic>\n                      might be a better IGRA for screening for latent TB infection in patients with cancer, although a direct comparison would be needed to definitively determine this.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid14428-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14428","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T11:33:46Z","timestamp":1735385626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Utility of Interferon\u2010\u03b3 Release Assays in the Diagnosis of Tuberculosis in Patients With Cancer"],"prefix":"10.1111","volume":"27","author":[{"given":"Marjorie V.","family":"Batista","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health AC Camargo Cancer Center  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-8929","authenticated-orcid":false,"given":"Joseph","family":"Sassine","sequence":"additional","affiliation":[{"name":"Infectious Diseases Section Department of Medicine University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-283X","authenticated-orcid":false,"given":"Fareed","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathit A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Medical Care Line Michael E. DeBakey Veterans Affairs Medical Center  Houston Texas USA"},{"name":"Infectious Diseases Section Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-9670","authenticated-orcid":false,"given":"Georgios","family":"Angelidakis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joumana","family":"Kmeid","sequence":"additional","affiliation":[{"name":"Gilbert and Rose\u2010Marie Chagoury School of Medicine Lebanese American University  Byblos Lebanon"},{"name":"Department of Internal Medicine Division of Infectious Diseases Lebanese American University\u2010Saint John's Hospital  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"El Chaer","sequence":"additional","affiliation":[{"name":"University of Maryland Greenebaum Comprehensive Cancer Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-6177","authenticated-orcid":false,"given":"Ella J.","family":"Ariza\u2010Heredia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Graviss","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research Houston Methodist Research Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Mulanovich","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy F.","family":"Chemaly","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.677"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00655-2019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m549"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2108501"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa031667"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121593"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.02.50"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4586-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.9.2715"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw838"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00157-2017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-02905-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.061"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.02.018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12794"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01329-3"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz048"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"221","article-title":"Interferon\u2010Gamma Release Assays for the Diagnosis of Latent Tuberculosis Infection: An Updated Review","volume":"43","author":"Moon H. 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