{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:48:50Z","timestamp":1787676530869,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR004419"],"award-info":[{"award-number":["UL1TR004419"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although infections are a leading cause of morbidity and mortality among patients with multiple myeloma (MM), the epidemiology of invasive fungal disease (IFD) is less well characterized in this population than in other hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nested 3:1 case\u2010control study of IFD at a large MM referral center to identify risk factors for IFD in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a cohort of 2960 patients, we identified 32 episodes of IFD among 31 patients between 01\/2011 and 06\/2019. There was a median of 3.6 years from MM diagnosis to IFD, and patients had a median of four lines of chemotherapy (range 1\u201312) before IFD. Seventeen (53%) had previous autologous hematopoietic cell transplants. At the time of IFD, 23 (72%) had progressive disease status. Fifteen (47%) and 13 (41%) had severe neutropenia and lymphopenia, respectively, and 18 (56%) had hypogammaglobulinemia. Microbiologic etiologies included\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 18),\n                      <jats:italic>Candida<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 6),\n                      <jats:italic>Cryptococcus<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 3),\n                      <jats:italic>Mucorales<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 3),\n                      <jats:italic>Histoplasma<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      = 1), and undetermined organism (\n                      <jats:italic>n<\/jats:italic>\n                      = 1). In the case\u2010control analysis, progressive disease status (OR 1.35,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) and neutropenia (OR 17.5,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) were significant risk factors for IFD. In addition, \u22653 prior lines of chemotherapy trended toward statistical significance (OR 5.6,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the largest detailed description of IFD epidemiology in MM patients and the largest controlled analysis of risk factors in this population. Overall, the risk of IFD was low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.14439","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T13:33:26Z","timestamp":1737207206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Invasive Fungal Diseases in Patients With Multiple Myeloma: Experience at a Large, Urban Referral Center"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-2023","authenticated-orcid":false,"given":"Emily","family":"Baneman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy Mount Sinai Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-3586","authenticated-orcid":false,"given":"Timothy","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-166X","authenticated-orcid":false,"given":"Risa","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallas","family":"Dunn","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-7510","authenticated-orcid":false,"given":"Sarah","family":"Taimur","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-886X","authenticated-orcid":false,"given":"Samantha E.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2009.03.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13532"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003621\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.853299"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010012\u20101210\u2010y"},{"issue":"8","key":"e_1_2_8_7_1","first-page":"1068","article-title":"The Epidemiology of Fungal Infections in Patients With Hematologic Malignancies: The SEIFEM\u20102004 Study","volume":"91","author":"Pagano L.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13178"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.114025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010019\u20103901\u2010y"},{"key":"e_1_2_8_11_1","unstructured":"B. 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A.Koneru A.Fassas G.Tricot et\u00a0al.Autopsy review in multiple myeloma reveals aspergillosis as a significant cause of death after high dose therapy especially with allotransplants.1997."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/313592"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00257"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)30206\u20106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126698"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.02.068"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010020\u201004125\u2010z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010015\u20104441\u20108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361241238518"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.14439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T16:37:33Z","timestamp":1762706253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.14439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/tid.14439"],"URL":"https:\/\/doi.org\/10.1111\/tid.14439","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]},"assertion":[{"value":"2024-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14439"}}