{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:59:48Z","timestamp":1777021188667,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Mycobacterium abscessus<\/jats:italic> complex is known to cause life\u2010threatening disease in lung transplantation (LT) recipients (LTRs). Therefore, many centers consider the presence of <jats:italic>M. abscessus<\/jats:italic> as a relative contraindication to LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective cohort study including all 4 LT centers in Canada. All LTRs transplanted in 2006\u20132016 with at least one respiratory sample positive for <jats:italic>M. abscessus<\/jats:italic> prior or posttransplantation were included. Pulmonary disease was defined using the American Thoracic Society criteria. Minimal follow\u2010up duration was 5\u00a0years after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2181 LTRs across Canada, 14 had <jats:italic>M. abscessus<\/jats:italic> disease after LT (incidence rate 1.1\/1000 transplant\u2010years) and 6 had pulmonary colonization (incidence rate 0.5\/1000 transplant\u2010years). Fifteen patients had <jats:italic>M. abscessus<\/jats:italic> cultured before LT. Among those with pretransplant <jats:italic>M. abscessus<\/jats:italic>, 53% (8\/15) developed <jats:italic>M. abscessus<\/jats:italic> infection posttransplant (6 disease, 2 colonization). Posttransplant disease was less frequent among those with microbiologic eradication before transplant (0% vs. 85.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). LTRs with pretransplant <jats:italic>M. abscessus<\/jats:italic> had comparable survival to those without <jats:italic>M. abscessus<\/jats:italic> (log rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.37). Among patients with pretransplant infection, mortality was higher in those who did not achieve microbiological eradication before transplantation (57.1% vs. 0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and those who developed disease after transplantation (66.7% vs. 0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>M. abscessus<\/jats:italic> is an uncommon cause of infection among LTRs. Survival among those with pretransplant <jats:italic>M. abscessus<\/jats:italic> infection was similar to that observed in noninfected LTRs. However, lack of eradication before transplantation was associated with higher posttransplant disease and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.70003","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T08:53:14Z","timestamp":1739868794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Mycobacterium abscessus<\/i> Complex Infections Among Lung Transplant Recipients: A Multicenter Retrospective Cohort Study in Canada"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-3398","authenticated-orcid":false,"given":"Roni","family":"Bitterman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Multi\u2010Organ Transplant Program University Health Network  Toronto Ontario 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