{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:48:43Z","timestamp":1777798123257,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In recent years, letermovir has been routinely used for cytomegalovirus (CMV) infection prophylaxis in patients receiving allogeneic hematopoietic stem\u2010cell transplantation (HSCT). The reduction effect of letermovir on CMV infection rates and the impact on survival have been studied, but other potential benefits of letermovir remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients who underwent first\u2010time allogeneic HSCT between October 2013 and August 2023. We compared the length of hospital stay between eras before and after the introduction of letermovir (\u201cnonletermovir group\u201d and \u201cletermovir group,\u201d respectively). Secondary outcomes included clinically significant CMV infection rates and hospitalization costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 59 patients were analyzed in the nonletermovir group and 65 patients in the letermovir group. The median length of hospital stay was 51 days in the nonletermovir group and 42 days in the letermovir group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Among standard\u2010risk disease patients, the letermovir group also had significantly shorter hospital stays (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0048). Additionally, the cumulative incidence of clinically significant CMV infection and grade II\u2013IV acute graft\u2010versus\u2010host disease were both lower in the letermovir group. Hospitalization costs were not significantly different between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The length of hospital stays after HSCT was observed to be shorter following the introduction of letermovir in this study. This reduction in hospital stays did not decrease hospitalization costs in relation to allogeneic HSCT, but it may alleviate the burden on both patients and healthcare providers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70008","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:03:39Z","timestamp":1740139419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reduction in Length of Hospital Stays for Allogeneic Hematopoietic Stem\u2010Cell Transplantation in the Letermovir Era"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-7476","authenticated-orcid":false,"given":"Hiroki","family":"Hosoi","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"},{"name":"Department of Transfusion Medicine Wakayama Medical University Hospital  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misato","family":"Tane","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wan","sequence":"additional","affiliation":[{"name":"Clinical Study Support Center Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Mushino","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"},{"name":"Division of Medical Information Wakayama Medical University Hospital  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sonoki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Wakayama Medical University  Wakayama Japan"},{"name":"Department of Transfusion Medicine Wakayama Medical University Hospital  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05474-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14171"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.293"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.12.497"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1551193"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.20.00170"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac687"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14526"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04660-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.03.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02323-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1400610"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30158-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0301-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003418"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.265769"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T16:37:42Z","timestamp":1762706262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/tid.70008"],"URL":"https:\/\/doi.org\/10.1111\/tid.70008","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"2024-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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