{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:03:07Z","timestamp":1782907387191,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 DK127250"],"award-info":[{"award-number":["K08 DK127250"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24\u2010AI146137"],"award-info":[{"award-number":["K24\u2010AI146137"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK070869"],"award-info":[{"award-number":["R01DK070869"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have suggested an increased risk of cytomegalovirus (CMV) viremia among Hepatitis C virus (HCV)\u2010uninfected recipients of kidney transplants from HCV\u2010RNA+ deceased donors (HCV D+\/R\u2212), but these studies featured small sample sizes and limited ability to address confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assembled a retrospective cohort of adult kidney transplant recipients at five US centers between 4\/1\/2015 and 12\/31\/2020 to determine the association between HCV D+\/R\u2212 transplants and the outcomes of CMV viremia (&gt;\u00a01000 IU\/mL), death\u2010censored graft failure, and mortality in the first posttransplant year compared to HCV D\u2212\/R\u2212 transplants. We generated highly similar matched cohorts of HCV D+\/R\u2212 and HCV D\u2212\/R\u2212 recipients based on attributes that affect the risk of CMV viremia. We matched exactly on center, CMV donor\/recipient serostatus, and antibody induction therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised 275 HCV D+\/R\u2212 recipients with a mean age of 52.5 years (SD = 10.7); 19% were CMV D+\/R\u2212, and 74% received anti\u2010thymocyte globulin induction. With variable ratio matching, 267 HCV D+\/R\u2212 recipients were matched to 996 HCV D\u2212\/R\u2212 recipients. CMV viremia occurred in 15% of HCV D+\/R\u2212 and 11% of HCV D\u2212R\u2212 recipients. In Cox regression, transplantation with an HCV\u2010RNA+ donor kidney was not associated with a significantly higher risk of CMV viremia (HR 1.3, 95% CI 0.89\u20131.92) or death\u2010censored graft loss (HR 0.61, 95% CI 0.31\u20131.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of CMV viremia was not significantly increased among HCV D+\/R\u2212 kidney recipients. Future studies should examine associations between donor\u2010derived HCV infection and clinical outcomes of CMV syndrome and disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.70011","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T14:50:05Z","timestamp":1741618205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of Cytomegalovirus Viremia Following Transplantation of Hepatitis C\u2010Viremic Donor Kidneys Into Uninfected Recipients: A Multi\u2010Center Retrospective Cohort Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Vishnu S.","family":"Potluri","sequence":"first","affiliation":[{"name":"Renal\u2010Electrolyte and Hypertension Division Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Clinical Epidemiology and Biostatistics University of Pennsylvania  Philadelphia Pennsylvania 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Hypertension Spencer Fox Eccles School of Medicine at the University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-791X","authenticated-orcid":false,"given":"Rachel","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Sise","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Kidney and Pancreas Transplantation Vanderbilt University Medical Center  Nashville Tennessee 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