{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:16Z","timestamp":1787016196324,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Clostridium difficile<\/jats:italic>\n                      (\n                      <jats:italic>C. difficile<\/jats:italic>\n                      ) infection is a frequent complication following hematopoietic stem cell transplant, contributing to increased morbidity in this population. Despite current infection prevention strategies, rates among posttransplant patients at some centers remain high. Oral vancomycin is a safe and well\u2010tolerated antibiotic that may be a potential adjunct to prevent\n                      <jats:italic>C. difficile<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the effectiveness of oral vancomycin in preventing\n                      <jats:italic>C. difficile<\/jats:italic>\n                      among allogeneic stem cell transplant patients and assess other posttransplant outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted comparing the rate of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      following allogeneic transplant in patients who received oral vancomycin versus no prophylaxis during hospitalization. The primary outcome was the development of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection within the first 100 days following transplant, defined as a positive stool toxin assay or PCR. Secondary outcomes included hospital length of stay, hospital\u2010acquired infections, overall mortality, graft\u2010versus\u2010host disease (GVHD), and rehospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 202 patients, one case of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      occurred in the prophylaxis group (1\/71, 1.4%) compared to 31 cases in the unexposed group (31\/131, 23.6%). Patients who received prophylaxis were significantly less likely to develop\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection during the study period (OR 0.046,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). No differences were observed between groups in hospital\u2010acquired infections, mortality, incidence of acute GVHD, and rehospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Prophylactic vancomycin was associated with a marked reduction in\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection in allogeneic transplant patients. Despite no significant impact on other clinical outcomes, there was a significant reduction in symptomatic\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection. Further prospective studies are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70025","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T09:54:09Z","timestamp":1742291649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prophylactic Vancomycin in the Primary Prevention of\n                    <i>Clostridium difficile<\/i>\n                    in Allogeneic Stem Cell Transplant"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-721X","authenticated-orcid":false,"given":"Brendon","family":"Fusco","sequence":"first","affiliation":[{"name":"Montefiore Einstein Comprehensive Cancer Center Albert Einstein College of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Tomita\u2010Barber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers Robert Wood Johnson School of Medicine  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway Township New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tyno","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson School of Medicine Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"McEntee","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson School of Medicine Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway Township New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Strair","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson School of Medicine Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Schaar","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson School of Medicine Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Cooper","sequence":"additional","affiliation":[{"name":"Montefiore Einstein Comprehensive Cancer Center Albert Einstein College of Medicine  New York 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Evaluation of the Performance of C. diff Quik Chek Complete and Toxin A + B (Clostridium difficile) DUO Diagnostic Tests Compared With Toxigenic Culture in the Diagnosis of Clostridium difficile Infection","volume":"66","author":"Yazisiz H.","year":"2020","journal-title":"Clinical Laboratory"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24896"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.12.672"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.06.021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy484"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac492.470"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044097"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.795"}],"container-title":["Transplant Infectious 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