{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:08:39Z","timestamp":1785247719025,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epstein\u2013Barr virus (EBV) viral load (VL) monitoring is recommended post\u2010transplant for EBV\u2010mismatched (donor EBV seropositive\/recipient EBV seronegative) solid organ transplant (SOT) recipients as a component of post\u2010transplant lymphoproliferative disorder (PTLD) prevention, but the optimal frequency and timing of EBV VL monitoring remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we investigated the incidence and timing of whole blood EBV DNAemia in EBV\u2010mismatched adult and pediatric SOT recipients, who had EBV VL monitoring as part of a pre\u2010emptive approach to PTLD prevention to optimize monitoring algorithms. We explored associations between donor\u2010acquired EBV DNAemia (DA\u2010EBV), defined as EBV DNAemia within 1\u00a0year post\u2010transplant, and donor and recipient characteristics, and determined the proportion who developed PTLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 257 D\n                      <jats:sup>+<\/jats:sup>\n                      \/R\n                      <jats:sup>\u2212<\/jats:sup>\n                      recipients (kidney\n                      <jats:italic>n<\/jats:italic>\n                      = 64, heart\n                      <jats:italic>n<\/jats:italic>\n                      = 75, liver\n                      <jats:italic>n<\/jats:italic>\n                      = 93, lung\n                      <jats:italic>n<\/jats:italic>\n                      = 25); 126\/257 (49.0%) developed DA\u2010EBV at a median of 83\u00a0days (Q1\u2013Q3: 50\u2013130\u00a0days) post\u2010transplant. Incidence of DA\u2010EBV varied by organ and was highest in liver (62.4%) and lowest in heart recipients (28.0%). PTLD was diagnosed in 38\/257 (14.8%) EBV\u2010mismatched recipients, 25\/162 (15.4%) children, and 13\/95 (13.7%) adults. DA\u2010EBV was uncommon in recipients less than 6\u00a0months old (3\/29, 10.3%) and among recipients less than 12\u00a0months with donors less than 12\u00a0months (2\/29, 6.9%); possible mechanisms of protection other than recipient passive maternal antibody and false\u2010positive donor serostatus are discussed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Monitoring for DA\u2010EBV should be focused on months 2\u20136 post\u2010transplant. Less frequent whole blood EBV VL monitoring is likely a safe option in recipients less than 6\u00a0months old and recipients 6\u201312\u00a0months old with donors less than 12\u00a0months old.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70042","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:46:05Z","timestamp":1745916365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence and Timing of Epstein\u2013Barr Virus Whole Blood DNAemia in Epstein\u2013Barr Virus\u2010Mismatched Adult and Pediatric Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-5582","authenticated-orcid":false,"given":"Catherine","family":"Burton","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics University of Alberta  Edmonton Alberta 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