{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:00:10Z","timestamp":1789052410798,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney transplantation (KT) is the preferred treatment for kidney failure, with living donor KT (LDKT) offering better outcomes and improved quality of life (QOL) than deceased donor KT. ABO incompatibility (ABOi) once restricted LDKT, but desensitization protocols now enable ABOi LDKT, expanding the donor pool with favorable outcomes. However, added risks of ABOi remain debated. We examined the impact of repeated infections on graft loss and death in both ABO\u2010compatible (ABOc) and ABOi LDKT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, nationwide Swiss Transplant Cohort Study from May 2008 to December 2022, including all ABOi LDKT patients. Clinically relevant infections (viral, bacterial, fungal, and parasitic) were analyzed as repeated adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 227 ABOi LDKT and 1172 ABOc recipients, 13% (183\/1399) had \u2265\u00a02 significant infections within the first 6 months. ABOi was independently associated to a higher infection risk (HR 1.21, 95% CI 1.10\u20131.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Patients with early recurrent infections were older, often female, and had ABOi LDKT. Patients with \u2265\u00a02 infections faced increased risks of graft loss, lower eGFR, and reduced QOL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ABOi LDKT patients face a higher risk of recurrent infections, especially within 6 months post\u2010KT, associated with reduced allograft function and lower QOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70084","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T12:50:12Z","timestamp":1753188612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Repeated Non\u2010Fatal Infections on Quality of Life and Graft Function in ABO\u2010Incompatible Kidney Transplants"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-1645","authenticated-orcid":false,"given":"Federica","family":"Bocchi","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Inselspital, Bern University Hospital  Bern Switzerland"},{"name":"Department of Nephrology and Dialysis Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Tenon  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Binet","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology Transplantation Medicine, Kantonspital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-6096","authenticated-orcid":false,"given":"Dela","family":"Golshayan","sequence":"additional","affiliation":[{"name":"Transplantation Center Department of Medicine Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Haidar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension HUG, Geneva University Hospital  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-912X","authenticated-orcid":false,"given":"C\u00e9dric","family":"Hirzel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Nephrology USZ, Zurich University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-4798","authenticated-orcid":false,"given":"Thomas","family":"Schachtner","sequence":"additional","affiliation":[{"name":"Department of Nephrology USZ, Zurich University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-5936","authenticated-orcid":false,"given":"Daniel","family":"Sidler","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Inselspital, Bern University Hospital  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.2000.00816.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510110079036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/frtra.2023.1240155"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514550"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"119","article-title":"Expanding the Donor Pool: Use of Marginal Donors for Solid Organ Transplantation","volume":"10","author":"Alexander J. W.","year":"1996","journal-title":"Clinical Transplantation"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V123589"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S360460"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000457"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.144"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.932171"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu309"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024853"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12234"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32091\u20109"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00540118"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14050"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13482"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004109"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12841216"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010012\u20109754\u2010y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2005.01207.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010051176"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12515"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11567"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1113"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac243"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr215"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000029"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv388"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.09.001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.01.152"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2024.12263"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16316"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000312"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000753"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:59:55Z","timestamp":1773053995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/tid.70084"],"URL":"https:\/\/doi.org\/10.1111\/tid.70084","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70084"}}