{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:01:18Z","timestamp":1783094478572,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Community\u2010acquired respiratory virus (CARV) infections are frequent and potentially severe in allogeneic hematopoietic stem cell transplant (allo\u2010HCT) recipients. However, their impact during the peri\u2010engraftment period remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective multicenter study, we assessed the characteristics, effects on neutrophil engraftment, and risk factors for lower respiratory tract disease (LRTD) progression and 100\u2010day mortality of symptomatic peri\u2010engraftment CARV infections [from Day \u22128 until Day +36 after stem cell infusion]. A total of 112 allo\u2010HCT recipients and 114 CARV episodes were included. Univariable and multivariable Cox regression analyses and cumulative incidence estimates were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median patient age was 51 years. Rhinovirus (47%) and respiratory syncytial virus (23%) were the most common pathogens. Half of the infections occurred before neutrophil engraftment (median day +18), and 50% progressed to LRTD. The 100\u2010day mortality rate was 17%, increasing to 27% in those with LRTD. CARV infection prior to engraftment was associated with delayed neutrophil recovery (Day +18\u00a0vs. +16;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) in multivariable cause\u2010specific Cox regression analysis (HR 0.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Multivariable analysis identified lymphocyte count &lt;0.2\u00d710\u2079\/L (HR 3.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.004) and active graft\u2010versus\u2010host disease (HR 2.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.004) as independent predictors of LRTD. Risk factors for 100\u2010day mortality included LRTD (HR 3.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.04), use of anti\u2010thymocyte globulin (HR 3.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.019), and bacterial coinfection (HR 4.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CARV infections during the peri\u2010engraftment allo\u2010HCT phase carry a high risk for delayed engraftment and LRTD in case of profound lymphopenia and GvHD. LRTD, ATG use, and bacterial coinfections contributed significantly to mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70101","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:34:24Z","timestamp":1757601264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterizing Respiratory Virus Infections During the Peri\u2010Engraftment Period of Allogeneic Hematopoietic Cell Transplant"],"prefix":"10.1111","volume":"27","author":[{"given":"Jos\u00e9 Luis","family":"Pi\u00f1ana","sequence":"first","affiliation":[{"name":"Department of Hematology INCLIVA Biomedical Research Institute Hospital Cl\u00ednico Universitario of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Mart\u00ednez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Hematology INCLIVA Biomedical 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