{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:28:48Z","timestamp":1790630928046,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory viral infections (RVIs) significantly impact patients with hematologic malignancies (HMs). During the 2023\u20132024 respiratory viral (RV) season, we observed a decline in SARS\u2010CoV\u20102\u2010related hospitalizations in our center compared to the two previous seasons. Given the changing epidemiology of RVIs in the post\u2010pandemic era, the low acceptance of SARS\u2010CoV\u20102 and influenza vaccination, and the availability of new respiratory syncytial virus (RSV) vaccines in 2023, we aimed to compare outcomes of RSV, influenza, and SARS\u2010CoV\u20102 infections in patients with HMs during the 2023\u20132024 RV season.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed adults with HMs diagnosed with RSV, influenza, or SARS\u2010CoV\u20102 between October 2023 and April 2024. The primary outcomes were lower respiratory tract infection (LRI), hospitalization, and 30\u2010day all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 503 patients with 536 consecutive RVIs: 50.0% with SARS\u2010CoV\u20102, 26.1% with RSV, and 22.2% with influenza (1.7% co\u2010infections). Among RSV\u2010infected patients, 50.7% developed LRI, compared to 41.2% with influenza and 39.2% with SARS\u2010CoV\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.076). The 30\u2010day all\u2010cause mortality was 9.3% for RSV, 7.6% for influenza, and 3.4% for SARS\u2010CoV\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.037). In the multivariable analysis, RSV was associated with higher LRI rate compared to SARS\u2010CoV\u20102, along with older age, refractory\/relapsed cancer, nosocomial infections, and lymphopenia. Older age, allogeneic hematopoietic cell transplantation, nosocomial infections, and LRIs were associated with increased mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      During the 2023\u20132024 RV season, the clinical impact of these viruses on patients with HMs remains significant, with higher morbidity and mortality from RSV, highlighting the persistent unmet need for better management strategies for RVIs in the post\u2010pandemic era.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid70113-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70113","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:25:19Z","timestamp":1759958719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Respiratory Syncytial Virus Exceeded SARS\u2010CoV\u20102 and Influenza in Lower Respiratory Infection and Mortality Rates Among Patients With Hematologic Malignancies During the 2023\u20132024 Respiratory Virus Season"],"prefix":"10.1111","volume":"27","author":[{"given":"Tali","family":"Shafat","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Spallone","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)  Basel Switzerland"},{"name":"Department of Infection Control Chief Quality Office, The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareed","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory 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