{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:59:21Z","timestamp":1770818361686,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vancomycin plus an antipseudomonal \u03b2\u2010lactam are common antibiotics used for lung transplant surgical prophylaxis, but the optimal post\u2010operative duration is unknown. The study objective was to assess the impact of a shortened antibacterial surgical prophylaxis duration on post\u2010operative acute kidney injury (AKI) in lung transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an IRB approved, single pre\u2010\/post\u2010test quasi\u2010experiment of lung transplant recipients who received post\u2010operative antibiotic prophylaxis from January 1, 2016\u2013September 30, 2020 (pre\u2010group) to October 1, 2020\u2013March 31, 2025 (post\u2010group). The intervention included modifying vancomycin (and cefepime) post\u2010operative prophylaxis durations to 72 h; the previous prophylaxis standard included continuing vancomycin until chest tube removal. The primary endpoint was incidence of AKI, defined by the KDIGO criteria, while receiving post\u2010operative vancomycin up to 14 days. Thirty\u2010day secondary outcomes included surgical site infection (SSI), treatment of lower respiratory\u2010tract infection, and isolation of multi\u2010drug\u2010resistant organisms (MDRO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety patients were included\u201445 pre\u2010 and 45 post\u2010intervention. Most patients were men (64.4%) and had a median (IQR) age of 63 (58\u201368) years. The most common indication for transplant was pulmonary fibrosis (37.8%). The incidence of 14\u2010day AKI was reduced when comparing pre\u2010 and post\u2010intervention groups (48.9%\u00a0vs. 28.9%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.052), with no differences in SSI (2.2%\u00a0vs. 2.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 1.0), treatment of lower respiratory tract infection (57.8%\u00a0vs. 73.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.120), and isolation of MDRO (15.6%\u00a0vs. 13.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.764). When accounting for baseline renal function, patients in the post\u2010intervention group had a significantly decreased odds of AKI (adjOR, 0.385; 95%CI, 0.154\u20130.959).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Implementation of a shortened post\u2010operative vancomycin prophylaxis duration protocol was associated with reduced odds of AKI in lung transplant recipients, with similar post\u2010operative infectious complications.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid70118-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70118","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:30:43Z","timestamp":1761406243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of a Protocol With a Shortened Vancomycin Prophylaxis Duration is Associated With Reduced Acute Kidney Injury in Lung Transplant Recipients: A Quasi\u2010Experimental Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Paige T.","family":"Stratton","sequence":"first","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Grace","family":"Fitzmaurice","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo J. Franco","family":"Palacios","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J.","family":"Alangaden","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Veve","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Henry Ford Hospital  Detroit Michigan USA"},{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004054"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2022.01.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/320901"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13589"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.03.019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13041"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010014\u20104062\u20103"},{"key":"e_1_2_11_9_1","first-page":"279","volume-title":"Psychosocial Care of End\u2010Stage Organ Disease and Transplant Patients","author":"Garrido G.","year":"2018"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CNQ.0000343135.19695.eb"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40248\u2010016\u20100075\u2010y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13592"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010020\u20101151\u20109"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.1372"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1757177420971850"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13896"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.08.002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19\u20101509"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20103640"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2201"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16743"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2376"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.12.013"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13518"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12746"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25486"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2021.239"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13538"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526924820933824"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.06.007"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000996"},{"key":"e_1_2_11_34_1","unstructured":"M.Lafaurie et\u00a0al. \u201cEfficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients a Multicentre Randomized Non\u2010Inferiority Trial. 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