{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:49:09Z","timestamp":1792165749729,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory viral infections (RVIs) can have distinct clinical presentations and outcomes in non\u2010lung solid organ transplant (SOT) recipients compared to non\u2010transplant and lung transplant patients. Understanding their impact is crucial for improving patient care and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study analyzed adult non\u2010lung SOT recipients with PCR\u2010confirmed symptomatic RVIs from eight Dutch hospitals (January 2013\u2013July 2024) to characterize clinical characteristics and outcomes of mono\u2010 and co\u2010infections and identify risk factors for intensive care admission or 30\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 603 RVIs were identified in 460 recipients (kidney: 501; liver: 75; pancreas\/islet of Langerhans: 4; combined: 23). The most common viruses were SARS\u2010CoV\u20102 (36%), influenza A\/B (29%), rhinovirus (14%), and RSV (7%). Influenza cases showed higher rates of fever (72%), common cold symptoms (37%), and myalgia (29%) than other viruses. Hospitalization occurred in 68% (384\/565). Factors independently associated with intensive care admission or 30\u2010day mortality included higher CURB\u201065 score (OR 1.91; 95% CI 1.36\u20132.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), radiologic infiltrates (OR 3.04; 95% CI 1.60\u20135.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), and SARS\u2010CoV\u20102 infection (OR 1.67; 95% CI 1.05\u20132.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). In contrast, influenza infection was associated with a lower risk (OR 0.21; 95% CI 0.07\u20130.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Co\u2010infections were not linked to worse outcomes compared to mono\u2010infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, RVIs in non\u2010lung SOT recipients were associated with high hospitalization and mortality rates. SARS\u2010CoV\u20102 posed the highest risk for complications, while influenza was associated with a lower risk of severe outcomes. No association was found between co\u2010infection and poor outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70128","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:24:18Z","timestamp":1762626258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiology and Clinical Impact of Confirmed Respiratory Viral Infections in Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"28","author":[{"given":"Manon L. M.","family":"Prins","sequence":"first","affiliation":[{"name":"LUCID\u2010Subdepartment of Infectious Diseases Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Internal Medicine Division Acute Internal Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst D.","family":"van Dokkum","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Leiden University Medical Center  Leiden the Netherlands"},{"name":"Health Campus Leiden University Medical Center  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko P. J.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology and Leiden Transplant Center Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten E.","family":"Tushuizen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"van der Helm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology and Leiden Transplant Center Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Spithoven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Amphia Hospital  Breda the Netherlands"},{"name":"Department of Internal Medicine Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Nephrology Haga Teaching Hospital  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard M.","family":"Scholten","sequence":"additional","affiliation":[{"name":"Department of Nephrology Haaglanden Medical Center  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Vollaard","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control National Institute for Public Health and the Environment  Bilthoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo G.","family":"Visser","sequence":"additional","affiliation":[{"name":"LUCID\u2010Subdepartment of Infectious Diseases Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert H.","family":"Groeneveld","sequence":"additional","affiliation":[{"name":"LUCID\u2010Subdepartment of Infectious Diseases Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Internal Medicine Division Acute Internal Medicine Leiden University Medical Center  Leiden the 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