{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:59:34Z","timestamp":1770818374116,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Treating\n                      <jats:italic>Mycobacterium avium<\/jats:italic>\n                      complex (MAC) infection pre\u2010lung transplant (LT) can be challenging to treat, given prolonged therapy and side effects. The impact of pre\u2010transplant MAC treatment on recurrence and outcomes post\u2010LT remains unclear, especially in patients with interstitial lung disease (ILD) who have a median survival of less than 2 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of adult LT patients at the Mayo Clinic who had positive MAC sputum cultures pre\u2010LT. The cohort was stratified and compared based on the type of treatment (complete, partial, or no treatment) for MAC pulmonary infection. The primary outcome was MAC recurrence post\u2010LT, and secondary outcomes were mortality, FEV\u20101, and FVC at 1\u2010year post\u2010LT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the cohort of 47 patients, 9 (19.1%) were partially treated and 11 (23.4%) were completely treated for MAC infection pre\u2010LT. Post\u2010transplant MAC pulmonary infection recurrence occurred in eight (17%) of the total cohort, with four (14.8%) in the non\u2010treated, four (44.4%) in the partially\u2010treated, and none (0%) in the completely treated patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.026). There was no difference in mortality in patients who had MAC recurrence post\u2010transplantation (13%\u00a0vs. 9.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.9) and those who were completely or partially treated, compared to non\u2010treated (0%\u00a0vs. 13%\u00a0vs. 13%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.9). The FEV1 and FVC at 1\u2010year post\u2010LT did not differ by the pre\u2010transplant treatment or post\u2010transplant MAC recurrence status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The role of treatment for MAC infection pre\u2010transplant is questionable, especially in patients with diseases like ILD who may not have enough wait time to complete therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70129","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:40:05Z","timestamp":1762278005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lung Transplant Outcomes Following Treatment of Pre\u2010Transplant MAC Pulmonary Infection"],"prefix":"10.1111","volume":"28","author":[{"given":"Prasanth","family":"Balasubramanian","sequence":"first","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Khanijo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad A.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Corro","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tathagat","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi","family":"Bag","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Pennington","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Haney","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Makey","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendelyn","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Brumble","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Allergy and Sleep, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia Z.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher A.","family":"Baz","sequence":"additional","affiliation":[{"name":"Department of Transplantation Division of Lung Failure and Transplant, Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604\u2010571ST"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.4.1234"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000003664"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102017\u2010210927"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102015\u2010207360"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13588"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00377\u20102022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.3669"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14361"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2023.100800"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:19:54Z","timestamp":1770812394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/tid.70129"],"URL":"https:\/\/doi.org\/10.1111\/tid.70129","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}