{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:40:48Z","timestamp":1776721248410,"version":"3.51.2"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n Beta\u2010lactam allergies (BLAs) are commonly reported and may include true allergy or adverse effects. BLAs can lead to the use of suboptimal antimicrobials, resulting in adverse outcomes. At our institution, cefazolin is the preferred surgical prophylaxis for renal transplant (RT), with clindamycin used for BLAs. There is limited data available examining outcomes with the use of non\u2010standard surgical site prophylaxis in RT.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study evaluated 1523 adult RT patients from December 1, 2019 to December 1, 2024, with 257 (16.9%) having a documented BLA. BLA reactions were classified as immediate\/allergic and non\u2010allergic. Secondary outcomes included surgical site infections (SSIs) within 30 days and\n Clostridium difficile<\/jats:italic>\n within 60 days, and were compared between groups that received cefazolin and clindamycin.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 13.0% of the population had true allergic\u2010type reaction. The most common BLA was to penicillins (71.2%), then cephalosporins (46%) or multiple classes (10.8%). Allergic\u2010type reactions were reported by 186 (72.4%), and non\u2010allergic reactions were reported by 35 (13.6%), with 12 patients reporting both types, and 24 without recorded reactions. The most common immediate\/allergic reaction was hives\/rash (155 patients). The most common non\u2010allergic reaction was gastrointestinal symptoms.<\/jats:p>\n \n For perioperative prophylaxis, 182 patients received clindamycin and 67 received cefazolin. There was no difference in\n C. difficile<\/jats:italic>\n in the first 60 days. There was a higher rate of SSI in the first 30 days in patients who received clindamycin (29\/182, 15.9%) compared to cefazolin (2\/67, 2.99%),\n p<\/jats:italic>\n \u00a0=\u00a00.006.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n BLA is commonly reported, but the type of reactions should be critically evaluated, as non\u2010standard antibiotics may increase SSI risk.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70130","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T17:20:16Z","timestamp":1762536016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of Beta\u2010Lactam Allergy and Outcomes Associated With Perioperative Antibiotic Choice in Renal Transplant Recipients"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-2056","authenticated-orcid":false,"given":"Annelise","family":"Nolan","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2649-6058","authenticated-orcid":false,"given":"Johanna","family":"Papanikolla","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8893-5487","authenticated-orcid":false,"given":"Sidney","family":"Marenkovic","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Pharmacy Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0265-0527","authenticated-orcid":false,"given":"Madeline","family":"Owen","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Pharmacy Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.084"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13168"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.11.201"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13907"},{"key":"e_1_2_9_11_1","volume-title":"Surgical Site Infection Event (SSI)","author":"National Healthcare Safety Network","year":"2025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13589"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200112270\u201000009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/589725"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b4ee9a"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:33:54Z","timestamp":1768206834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/tid.70130"],"URL":"https:\/\/doi.org\/10.1111\/tid.70130","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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